A case in a 71-year old male of Fulminant myocarditis with complete atrioventricular block after mRNA COVID-19 vaccination (Onishi et al.): McCullough comments on this fatal Eosinophilic Myocarditis

following mRNA Injection Pfizer mRNA vaccine; this myocarditis (caused by mRNA-LNP itself?) was very rapid & fatal (fulminant) and not mild and and transient as told to us by CDC & Health Canada

https://pubmed.ncbi.nlm.nih.gov/36779079/

‘A 71-year-old man was transferred urgently to our hospital after collapsing near his home post the first shot of the BNT162b2 coronavirus disease 2019 vaccine (Pfizer-BioNTech, Comirnaty®). Immediately after arrival at our hospital, cardiac arrest due to complete atrioventricular block with no ventricular escaped beats was observed on electrocardiogram. Echocardiography showed preserved left ventricular ejection fraction, however, diffuse severe hypokinesia was revealed after 3 weeks, and he died 3 months after admission because of worsening heart failure. An autopsy examination revealed eosinophilic myocarditis or hypersensitivity myocarditis with extensive fibrosis and widespread myocardial dropout throughout the heart.’

McCullough’s always informative writing and stack on this tragic case:

‘Onishi et al reported a A 71-year-old man with type 2 diabetes mellitus and essential hypertension who was found collapsed following the administration of the first dose of BNT162b2 COVID-19 vaccine. It was estimated from the inoculation record that approximately 4–5 h had passed since the vaccination. He had many complications with the resuscitation and died after 83 days.

Onishi N, Konishi Y, Kaneko T, Maekawa N, Suenaga A, Nomura S, Kobayashi T, Kyo S, Okabayashi M, Higami H, Oi M, Higashitani N, Saijo S, Nakazeki F, Oyamada N, Jinnai T, Okuno T, Shirase T, Kaitani K. Fulminant myocarditis with complete atrioventricular block after mRNA COVID-19 vaccination: A case report. J Cardiol Cases. 2023 May;27(5):229-232. doi: 10.1016/j.jccase.2023.01.004. Epub 2023 Jan 27. PMID: 36779079; PMCID: PMC9906563.

The main teaching points are:

1. COVID-19 vaccine induced myocarditis can be very rapid in onset and ultimately fatal. We should not assume cases are mild and and transient as told to us by public health agencies.

2. Older patients have lesser reserves to survive a cardiac arrest.

3. Eosinophilic myocarditis is caused by the mRNA-lipid nanoparticle directly as there was probably insufficient time to produce enough Spike protein to cause fulminant damage and cardiogenic shock.

4. Fatal myocarditis is an unacceptable complication in even one case since the COVID-19 vaccines have not been shown to reduce transmission or the composite of hospitalization and death in randomized trials. This life was lost for no possible theoretical benefit.

5. Future mRNA vaccines for influenza and other illnesses are likely to cause the same fatal eosinophilic myocarditis as this appears to be related to the mRNA-LNP complex and not the Spike protein.’

Fatal Eosinophilic Myocarditis after mRNA Injection