Additional evidence (shared by ANW subscriber) showing dysregulation & subversion (IgG 4 class switch) of host immune response by Malone et al. mRNA gene vaccine & why NO shot is/was needed & the

danger of boosters that drive 'class-switch' towards immune tolerance (see my prior stacks below on immune tolerance class switch to IgG4 adds to study); key finding: mRNA boosters PROMOTES cancers

IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein

Exploring the possible link between the spike protein immunoglobulin G4 antibodies and cancer progression

Abstract

Key finding:

‘Repeated inoculation with messenger RNA (mRNA) vaccines elicits immunoglobulin G4 (IgG4) antibody production. Such an increase in the concentration of specific and non-specific IgG4 antibodies allows the growth of some types of cancer by blocking the activation of effector immune cells.

This work proposes the hypothesis that cancer growth may be indirectly promoted by increased concentrations of non-specific IgG4 antibodies by the following mechanisms: 1) IgG4 antibodies can bind to anti-tumor IgG1 antibodies and block their interaction with receptors located on effector cells, thus preventing the destruction of cancer cells, 2) IgG4 can interact with fragment crystallizable gamma receptor IIb (FcγRIIB) inhibitory receptors, thus reducing effector functions of innate immune cells, and 3) targeting of specific epitopes by IgG4 could be oncogenic by inducing the production of a microenvironment that can promote cancer development.

This article reviews the supporting literature and suggests several experimental protocols to evaluate this hypothesis in the context of repeated inoculation with mRNA vaccines. Additionally, this work proposes some management options aimed at reducing the unfavorable molecular consequences that could mediate cancer development when encountering high concentrations of IgG4 antibodies.’

See also:

My prior substacks on immune tolerance and class switch to IgG4:

See also:

See also:

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