ANCA vasculitis happens when autoantibodies (ANCAs) attack small blood vessels; this may impact the kidneys; a case of ANCA-Associated Vasculitis following the COVID Pfizer vaccine in a 77-year old

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285210/

‘a case of new-onset renal-limited ANCA-associated vasculitis (AAV) in a 78-year-old woman with previously normal kidney function after receiving the Pfizer-BioNTech COVID-19 vaccine. The patient developed acute kidney injury with proteinuria and microscopic hematuria with many dysmorphic red blood cells in the urine. Anti-myeloperoxidase antibody titer was elevated. Kidney biopsy showed pauci-immune crescentic necrotizing glomerulonephritis. Kidney function improved after treatment with steroids and rituximab. Our patient had normal routine laboratory testing before the vaccination.’

Figure 1

Light microscopy of glomerulus showing segmental fibrinoid necrosis (left side of tuft) and epithelial crescent formation at the top of the glomerulus (periodic acid–Schiff, ×400).