Antibody-dependent enhancement of infection (ADEI) can occur when non-neutralizing antibodies or antibodies at sub-neutralizing levels bind to viral antigens without blocking or clearing infection;
this was and remains a serious issue when using these sub-optimal non-sterilizing, non-neutralizing COVID mRNA technology vaccines; ADEI can exacerbate severity of COVID
Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies
One potential hurdle for antibody-based vaccines and therapeutics is the risk of exacerbating COVID-19 severity via antibody-dependent enhancement (ADE). ADE can increase the severity of multiple viral infections, including other respiratory viruses such as respiratory syncytial virus (RSV)9,10 and measles11,12. ADE in respiratory infections is included in a broader category named enhanced respiratory disease (ERD), which also includes non-antibody-based mechanisms such as cytokine cascades and cell-mediated immunopathology (Box 1). ADE caused by enhanced viral replication has been observed for other viruses that infect macrophages, including dengue virus13,14 and feline infectious peritonitis virus (FIPV)15. Furthermore, ADE and ERD has been reported for SARS-CoV and MERS-CoV both in vitro and in vivo.’
‘ADE has been documented to occur through two distinct mechanisms in viral infections: by enhanced antibody-mediated virus uptake into Fc gamma receptor IIa (FcγRIIa)-expressing phagocytic cells leading to increased viral infection and replication, or by excessive antibody Fc-mediated effector functions or immune complex formation causing enhanced inflammation and immunopathology (Fig. 1, Box 1).’
‘Enhanced disease and immunopathology are caused by excessive Fc-mediated effector functions and immune complex formation in an antibody-dependent manner. The antibodies associated with enhanced disease are often non-neutralizing. ADE of this type is usually examined in vivo by detecting exacerbated disease symptoms, including immunopathology and inflammatory markers, and is most clearly associated with respiratory viral infections. RSV and measles are well-documented examples of ADE caused by enhanced immune activation.’
a, For macrophage-tropic viruses such as dengue virus and FIPV, non-neutralizing or sub-neutralizing antibodies cause increased viral infection of monocytes or macrophages via FcγRIIa-mediated endocytosis, resulting in more severe disease. b, For non-macrophage-tropic respiratory viruses such as RSV and measles, non-neutralizing antibodies can form immune complexes with viral antigens inside airway tissues, resulting in the secretion of pro-inflammatory cytokines, immune cell recruitment and activation of the complement cascade within lung tissue. The ensuing inflammation can lead to airway obstruction and can cause acute respiratory distress syndrome in severe cases. COVID-19 immunopathology studies are still ongoing and the latest available data suggest that human macrophage infection by SARS-CoV-2 is unproductive. Existing evidence suggests that immune complex formation, complement deposition and local immune activation present the most likely ADE mechanisms in COVID-19 immunopathology. Figure created using BioRender.com.
https://www.nature.com/articles/s41564-020-00789-5
I warned people in February of 2021 about ADE. They said I was a "Science denier."
Notes..
1. An old post of mine from the early days . Some of you may like the simplification, and explanation I penned, on ADE as many do not understand the topic .
2. Note this is the draft (aplologies) and may have a few errors in spelling etc. Can't find the final copy at present, but very few changes. It was part of a series I originally did in a FB group as a group expert.
3. I left FB a long time ago because they constantly censored ALL truth and tens of thousands of doctors and scientists.
GET OFF FB as they aidded and abetted MASS MURDER, and violate high level laws like the Constitutiom ! .
4. ADE ' also goes by "others names". ADE is a serious RISK or disadvantage that has been known for devades. The name ADE isn't always obvious.
Stay away from vaccines or get PROPER informed consent .
Informed consent is ALWAYS three parts
1. Reward
2. Risks
3. ALTERNATIVE treatments !
Last and important ..
YOU NEVER NEVER NEVER mass vaccinate a HEALTHY POPULATION.
This is OUTRIGHT malfeasance. Ref experts as
Dr. Geert Vanden Bossche
Dr. Luc Montanier
Dr. Sucharit Bachdi
Dr. Michael Yeadon
Dr. Dolores Cahill
Dr. Sherry Tenpenny
Dr. Merril Nass and many more
My ...Cut and paste follows ...
Frankly, let me begin by saying ' ADE (Antibody Dependent Enhancement) is just one of many risks with the CoVid jabs .
Most do not understand this topic, and I want to get it out of the way . ( This is part a series of SEVERAL risks that few understand )
Although this is somewhat an over-simplification (as proper or full explanation requires an understanding of immunology AND considerable vaccine expertise or VIROLOGY) , "ADE"......(thanks to many docs that taught me)
Summarized , - is the fact that NO living species, or organism. simply dies - without a fight .
This is a built into evolution of why ALL species survive . (Viruses are technically "species "- and have classifications- such as phenotypes )
Naturally, if your too were in a life threatening fight - then you too would and should fight for your life . Otherwise, your opponent will kill you.
This is true of a wolf, a lion, an elephant or a bird, a dog, a bee , a former dinosaur, or an ant.
It is also true of " intelligent nature" of bacteria and viruses that we identify as pathogens in science.
Perhaps, you already know that bacteria attacked by antibiotics, or our immune system, will do their best to survive .
They, (bacteria) to survive , go deep into the bowel and biofilm. They will also line up into tight contiguous formations , to protect each other and resist -, similar to police lining up side by side to stop or slow civil disobedience, or bees swarming to threaten a superior opponent, such as a bear .
As you have likely and correctly heard , bacteria can even become ANTI-BIOTIC resistant. THIS MAKES them a greater threat .( ADE is similar)
This makes the surviving anti- biotic resistant bacteria, as - FAR MORE dangerous. Why?
Antibiotics no longer work to kill them, as they have now LEARNED a "work around" to SURVIVE.
When a person has been vaccinated with the "experimental CoVid jab," or for that matter any vaccine containing pathogens and toxic adjuvants, your body will create a resistance or "anti-body".
If the CoVid virus or any future similar Corona virus, including the common cold or seasonal influenza, - then ENTERS your body at any time in the future, (assuming) if the vaccine created that antibody , ........THEN the virus has ONLY two choices.
It can DIE or it can try and "fight for it's life" and find a "workaround. "
In the case of VIRUSES they MUTATE - if they survive by that work-around.
Now, if that happens, you potentially are in serious big trouble (due to being vaccinated), because the human body NOW has a mutated virus that didn't die BUT survived , somewhat similar - to an antibiotic that lived or became a resistant bacteria.
This is why NATURAL IMMUNITY is so superior and less harmful. Sadly natural immunity DOES NOT MAKE MONEY and is being hidden and censored!
The end RESULT over time is that a mutated virus might become FAR MORE LETHAL and will potentially not just kill you, but others if you spread it.
*** Added IMPORTANT NOTE.
Re VIRAL MUTATIONS.....
A MUTATED VIRUS that your body, - or nature, - or vaccines "helped create" as the virus resisted death and found a workaround via mutation- , DOES NOT usually become worse .
Often, it will make a mutation that can be LESS virulent (less deadly. or technically lower morbidity and lower mortality ) and NOT as easily transmittable. **** end edit
In short TWO - KEY CHARACTERISTICS of all viruses. are "transmissability and virulence."
Mutations so far in the virus have been very small (around 1 percent change or less change per mutation. However most experts consider this virus a very smart FAST MUTATING virus. (implying it was man made in a lab ' more later)
The simple tALL IMPORTANT takeaway about ADE. - is that no species dies without a fight . Viruses in that FIGHT can either DIE or MUTATE .
The vaccine therefore is ACTUALLY causing PRESSURE on the Sars CoV-2 virus and THUS forcing the virus to mutate and become far more dangerous.
This is a principle problem that was FULLY CREATED by the vaccine.
Anyone that says the unvaccinated are the problem is a "Bold faced liar" , and that I can prove in court by well established SCIENCE FACT .
This is JUST one serious risks of CoVid vaccines. There are many risks and the best way around them is DO NOT GET vaccinated .
SUB TOPIC - HUMAN IMMUNE SYSTEM starts here....
Pathogens by the way , are also called antigens.
So in the study of immunoly antigens are the bad guys, and "antibodies" produced by B cells- are just one of the MANY types of good guys.
Often , and THIS TOO IS IMPORTANT our human immune system never even resorts to using antibodies (B cells) . Why?
Humans, over billions of years of evolution have TWO basic types of immunity which is alnost always a discussion involving white blood cells or leukocytes.
These two basic types that are called the A. BUILT in or INATE ARM of our human immune system , and the
B. secondary arm which is usually called the adaptive or humoral arm of immunity .
Often our built in inate arm will kill the pathogen without ever needing to call in reinforcements from the acquired or humoral arm .
NOTE - The adaptive or humoral arm of human immune takes a full 7 to 10 days to kick in . It is a highly intelligent system that only responds AND LEARNS how to attack a pathogen when it receives chemical messengers, and gets educated from interleukins and many other big names like tumor necrosis factor (TNF) .
Whereas , the acquired or humoral arm is SLOW TO REACTand is primarily about B and T cells , our early built in inate arm goes to work IMMEDIATELY attacking pathogens by numerous complex mechanisms at its disposal, with a completed vast array of fighting cells with names like macrophages , neutrophils, dendritic cells, eosinophils, natural killer or NK cells and many more.
SUB TOPIC - HUMAN IMMUNE SYSTEM ends here ...
SUB TOPIC - Antibodies
Theoretically the CoVid jabs are not true vaccines at all. They have taken messenger RNA (mRNA) and technically it forces cells to make the spike protein (and S1 protein . The B and T cells in the humoral arm will then be theoretically educated, so that in future if you get the CoVid virus , your HUMORAL or acquired arm of T and B cells will spring into action IMMEDIATELY without the normal 7 to 10 date waiting period.
But here is sone HUGE PROBLEMS .
All of the CoVid vaccines were based ON the original genome sequencing of the FIRST NON MUTATED virus .
These vaccines are ALREADY OUT OF DATE and largely useless on new mutated strains like the delta . This is PROVEN science.
But worse , the human body varies dramatically and we all have different levels of immunity . As we age , our red bone marrow decreases dramatically where leukocytes are born, educated and delivered. Old people, btw - have very weak responses, and frankly have terrible antibody responses. In essence giving the jab to seniors is ALL risk and no reward. Studies in Norway immediately pointed this out . Pfizer has ADMITTED THIS!
So why would anyone understanding this give these experimental vacvines to seniors. Children have fantastic immunity a d babies are born with100 percent red marrow. CHILDREN have no need to be vaccinated and the jab puts them at greater health risk by fact . A study in England proved this.
Here is another fact . Your human body does not just make onetyoe of antibody .
Your body in response to the jab can make binding, non binding , non sterilizing or non neutralizing antibodies THAT ALL DO NOTHING .
The ONLY antibody that will technically work is called a neutralizing or sterilizing antibody. All others fail. But consider this , if everything went perfect (and it wont ) the next time you contract a mutated form IF you do have a n antibody, you will FORCE that virus to fight fir its life.
IF it wins and mutates as I discussed above, in a fight for it's life. you have a much bigger problem. Another factor is that by immediately forcing the humoral arm to jump into action, the odds of an unbalanced immune response is more likely. This has been proven by the CDC in the annual influenza vaccine.
I had parallel research about TWO other Corona viruses - the common cold and the seasonal.i influenza virus.WITH LINKS but FB immediately caught those links TO REAL DOCTORS and real CDC research and immediately delayed my entire post.