Artificial sweetener erythritol in STEVIA and cardiovascular event risk? major adverse cardiovascular events (MACE; includes death, nonfatal myocardial infarction, stroke) atherothrombotic disease
atherothrombotic disease risk; (adjusted hazard ratio (95% confidence interval), 1.80 (1.18–2.77) and 2.21 (1.20–4.07), respectively); erythritol enhanced platelet reactivity in vitro and thrombosis
‘In initial untargeted metabolomics studies in patients undergoing cardiac risk assessment (n = 1,157; discovery cohort, NCT00590200), circulating levels of multiple polyol sweeteners, especially erythritol, were associated with incident (3 year) risk for major adverse cardiovascular events (MACE; includes death or nonfatal myocardial infarction or stroke).
Subsequent targeted metabolomics analyses in independent US (n = 2,149, NCT00590200) and European (n = 833, DRKS00020915) validation cohorts of stable patients undergoing elective cardiac evaluation confirmed this association (fourth versus first quartile adjusted hazard ratio (95% confidence interval), 1.80 (1.18–2.77) and 2.21 (1.20–4.07), respectively). At physiological levels, erythritol enhanced platelet reactivity in vitro and thrombosis formation in vivo.
Finally, in a prospective pilot intervention study (NCT04731363), erythritol ingestion in healthy volunteers (n = 8) induced marked and sustained (>2 d) increases in plasma erythritol levels well above thresholds associated with heightened platelet reactivity and thrombosis potential in in vitro and in vivo studies…
findings reveal that erythritol is both associated with incident MACE risk and fosters enhanced thrombosis. Studies assessing the long-term safety of erythritol are warranted.’
Good Doctor I feel this is a misdirection away from the bio weapon shot that is killing everyone through heart attacks, for athletes with a lot of publicity they cannot totally control and everyone else.. This ingredient has not been injected into Billions of people over and over and over again with all kinds of poisonous ingredients, including graphene and snake venom... These cardio vascular so called doctors have known about this ingredient along with everyone else, why now with the ALARM, like they truly care.. Every formulation of Stevia does not have this ingredient, but all of a sudden they want to "Raise the Alarm, and say " This is something we should be looking into LOL" I feel it is BS, we know these doctors do not care, otherwise they would be raising the alarm on the Clot Shot, but nooooooooo lets look at Stevia LOL... Look over at STEVIA for the reason for all the deaths from Heart Attacks, don't look behind the door at thee real culprit, the Bio Weapon Poison..
Is this real, or just another way excuse to explain away the heart conditions we are seeing on the rise??