COVID vaccine studies that show us clearly the devastating failure of the COVID vaccines (mRNA) that are non-sterilizing (do not stop infection or transmission) & actually bind & enhance infection

We underestimated the interplay between the virus & host immune system, this ecosystem, where the sub-optimal immune pressure from the non-neutralizing vaccinal antibodies drives variants

We have enhanced susceptibility (infection in the vaccinated) while also have reduced severe disease in the lower respiratory tract (deep in the lung). This is not a usual situation. Why?

Which studies?

These three show that the induced vaccinal antibodies (Abs) (non-neutralizing) bind to the virus’s spike and enhance the infectiousness of the virus to the vaccinated person. The infectious behavior of the virus cannot be accounted for by the virus itself. Properties intrinsic to the virus. We argue that infectiousness must be looked at from the view of the non-neutralizing Abs that bind and enhance infectiousness in the vaccinated. In short, the non-neutralizing Abs give the virus the property of increased infectiousness. Enhanced infectiousness.

1)Yahi et al.: Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination?

2)Liu et al.: An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies

3)Lempp et al.: Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies

Then additional researchers shows us why vaccinees are less vulnerable to severe disease in the lower lung, respiratory tract. Researchers show that the very same non-neutralizing Abs in the upper respiratory tract (URT) work in the lower respiratory tract (LRT) and prevents fusion of infected cells with non-infected cells that prevent the formation of syncytia and those syncytia is linked (correlated) to severe disease.

The ‘common’ denominator that is determining the infectiousness and severe nature of the virus is the non-neutralizing Abs. It binds in the URT and enhances infectiousness yet binds in the LRT and prevents severe disease. The concern is that this blocking of severe disease in the LRT may be overcome in time (lose their protective effect) and we run the risk if we continue with the non-neutralizing vaccines, of generating both infectious and severe lethal, virulent variants. I am trying to explain this complex issue so bear with me for its complex too for me;-)

1)Asarnow et al.: Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia

These researchers showed us that with time, the sub-optimal immune pressure on viral infectiousness (the spike protein) was overcome by variants and Omicron emerged. The Omicron is now near completely resistant to the Abs generated against spike protein.

1)Hoffmann et al.: The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic

These researchers also showed us that there will be selection by the virus to overcome the sub-optimal pressure. The population is exerting immune pressure (sub-optimal) on virus virulence via non-neutralizing Abs. The virus became resistant to the neutralizing Abs and the non-neutralizing Abs grew in dominance and the non-neutralizing Abs at present, prevent transfection (drives severe disease) in the LRT.

1)Martin et al.: The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages

2)Van Egeren et al.: “Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein”