Doxycycline (over macrolides) results in better clinical outcomes with a shorter time to defervescence and to chest X-ray improvement among children with macrolide-resistant Mycoplasma pneumoniae

(MRMP) pneumonia, white lung; treatment is challenging & doxycycline seems critical in fighting this pneumonia; The Wellness Company's (TWC) emergency medical kit contains doxycycline, ivermectin etc.

Dec 05, 2023

Is what’s happening, ‘white lung' pneumonia, being reported in China a real epidemic, pandemic? Or a new psyop? Continuing on from the fraud PCR driven (false positive) fraud non-pandemic (IFR of 0.05% in persons 70 and under)?

The Wellness Company’s emergency kit contains doxycycline.

Emergency Preparedness kit of 8 essential medications to have on hand:

kit seen here:

Link:

https://www.twc.health/products/emergency-preparedness-kit?ref=Paul

We have to be prepared as parents and if this emerging Mycoplasma pneumoniae (MRMP) pneumonia in China that is being reported among children (possible that it may not be related) in the US too is credible, whether it is due to the immune system subversion and damage of lockdowns or the COVID mRNA technology gene vaccine (Bourla, Malone, Bancel, Sahin, Kariko, Weissman etc.), then The Wellness Company (TWC, found at TWC.health) emergency preparation kit is vital. It contains 8 key medications (prescription) as well as guide books that indicates the many conditions and illness that the medications cover.

Link:

https://www.twc.health/products/emergency-preparedness-kit?ref=Paul

Don't get caught unprepared - keep The Wellness Company's Medical Emergency Kit in your medicine cabinet!

The Wellness Company's prescription-only Medical Emergency Kit provides you with a carefully selected assortment of vital medications, preparing you for those unpredictable moments in life. Our kit ensures access to proven treatments like Ivermectin, arming you with confidence in the face of unforeseen medical emergencies.

https://www.mdpi.com/2079-6382/10/2/192

‘study aimed to analyze the efficacy of macrolides and doxycycline with regard to the presence of macrolide resistance…

analyzed children with MP pneumonia during the two recent epidemics of 2014–2015 and 2019–2020 from four hospitals in Korea.

Nasopharyngeal samples were obtained from children with pneumonia for MP cultures and polymerase chain reaction (PCR). Macrolide resistance was determined by the analysis of 23S rRNA gene transition. Time to defervescence and to chest X-ray improvement were analyzed.

Of 145 cases, the median age was 5.0 years and MRMP accounted for 59 (40.7%). Among macrolide-susceptible MP (MSMP), 78 (90.7%) were treated with macrolides and 21 (35.6%) in the MRMP group with doxycycline. In MRMP pneumonia, shorter days to defervescence (2 vs. 5 days, p < 0.001) and to chest X-ray improvement (3 vs. 6 days, p < 0.001) in the doxycycline group than in the macrolide group was observed, whereas no differences were observed among children with MSMP pneumonia.

Compared to macrolides, treatment with doxycycline resulted in better outcomes with a shorter time to defervescence and to chest X-ray improvement among children with MRMP pneumonia.’

Figure 2. Cumulative incidence analysis of fever and chest X-ray improvement according to antibiotic group in children with macrolide-resistant Mycoplasma pneumoniae pneumonia. (a) Time to resolution of fever; (b) time to chest X-ray improvement in children treated with macrolides only or doxycycline (* including macrolides changed to doxycycline and doxycycline only).

acrolide resistance in MP pneumonia in children has been an increasing conundrum due to limited alternative treatment options. In this study, we evaluated the clinical response to macrolides and doxycycline among children in macrolide-susceptible and macrolide-resistant cases. Among MSMP cases, there was no significant difference in clinical efficacy between macrolides and doxycycline when assessed by duration of fever or days to chest X-ray improvement after initiation of antibiotics. However, when comparing the response in MRMP, time to defervescence was reduced by 3 days and chest X-ray improvement was seen 3 days earlier in children treated with doxycycline compared to macrolides. Thus, cases with macrolide resistance showed significantly more rapid improvement of symptoms and radiologic findings with doxycycline compared with macrolides.

Doxycycline was used initially in a small number of cases among children of older ages in the 2019–2020 cohort based on the consideration of the high local macrolide resistance rate of up to 84.5%; there have been reports on the efficacy and safety of doxycycline in children and current recommendations are that children with moderate to severe disease may benefit from macrolides or tetracyclines (for children >7 years) [1,7,9]. The majority of cases which switched from macrolide to doxycycline were also in 2019–2020 (Table S1). The trend for prescription of doxycycline was related to an update in treatment guidelines for MP pneumonia in children in Korea in 2019, which recommends doxycycline as a second line therapy [10]. On the other hand, although over 40% of the subjects in this study were macrolide resistant, only 20% were treated with doxycycline as the final drug. This presumably attributes to the reluctancy of use of doxycycline in children. Taken together, macrolides stand as the first-line therapy in children; however, the difference between the two drugs in time to defervescence and chest X-ray improvement among cases with MRMP supports the benefits for switch to doxycycline in a timely manner.’

Order here:

https://www.twc.health/products/emergency-preparedness-kit?ref=Paul

The 8 therapeutics are (https://www.twc.health/products/emergency-preparedness-kit?ref=Paul):

Amoxicillin-Clavulanate (generic Augmentin) 875/125 mg - 28 tablets
this is a combination prescription antibiotic. Amoxicillin is a penicillin antibiotic that fights bacteria in the body. Clavulanate potassium is a beta-lactamase inhibitor that helps prevent certain bacteria from becoming resistant to amoxicillin. https://www.drugs.com/amoxicillin_clavulanate.html
Azithromycin (generic Z-Pak) 250 mg - 12 tablets
Azithromycin can fight a wide range of bacteria, including many in the Streptococcus family. It can stop harmful bacteria from growing.
Healthcare providers tend to use this drug to treat mild-to-moderate infections of the lungs, sinuses, skin, and other body parts.
A doctor may prescribe azithromycin to treat the following bacterial infections:
- sinus infections related to Moraxella catarrhalis or Streptococcus pneumoniae
- community-acquired pneumonia related to Chlamydia pneumoniae, Haemophilus influenzae, or S. pneumoniae
- chronic obstructive pulmonary disease (COPD) complications related to M. catarrhalis or S. pneumoniae
- some skin infections related to Staphylococcus aureus, Streptococcus pyogenes, or Streptococcus agalactiae
- tonsillitis related to S. pyogenes
- urethritis and cervicitis related to Chlamydia trachomatis
- chancroid genital ulcers (in males) related to Haemophilus ducreyi
- certain ear infections in children aged 6 months and over, such as those related to M. catarrhalis. https://www.medicalnewstoday.com/articles/325721#what-does-it-treat
Doxycycline Hyclate 100 mg - 60 capsules
Doxycycline hyclate is an antibiotic that treats many conditions, including acne, chlamydia, sinus infection, and urinary tract infection (UTI). It's taken by mouth, typically once or twice daily. It come as capsules, tablets, and a liquid syrup. Side effects of doxycycline hyclate include stomach upset, nausea, and vomiting. https://www.goodrx.com/doxycycline-hyclate/what-is
Metronidazole (generic Flagyl) 500 mg - 30 tablets

Metronidazole is an antibiotic that is used to treat bacterial infections of the vagina, stomach, liver, skin, joints, brain and spinal cord, lungs, heart, or bloodstream. https://www.drugs.com/metronidazole.html

Trimethoprim-Sulfamethoxazole (generic Bactrim) 800/160 mg - 28 tablets
Sulfamethoxazole and trimethoprim combination is used to treat infections including urinary tract infections, middle ear infections (otitis media), bronchitis, traveler's diarrhea, and shigellosis (bacillary dysentery). This medicine is also used to prevent or treat Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP), a very serious kind of pneumonia. https://www.mayoclinic.org/drugs-supplements/sulfamethoxazole-and-trimethoprim-oral-route/description/drg-20071899

Ivermectin 18mg - 7 compounded capsules
Fluconazole (genric Diflucan) 150 mg - 2 tablets
Fluconazole is an antifungal medicine that is used to treat infections caused by fungus, which can invade any part of the body including the mouth, throat, esophagus, lungs, bladder, genital area, and the blood. https://www.drugs.com/mtm/fluconazole.html
Ondansetron (generic Zofran) 4mg - 6 tablets
Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.
Ondansetron is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment. https://www.drugs.com/ondansetron.html

Don't get caught unprepared - keep The Wellness Company's Medical Emergency Kit in your medicine cabinet!

After completing your order, you'll fill out a short intake form that our doctors will use to approve your suitability for your the prescription kit.

Each kit is purposefully designed as an emergency supply tailored for ONE ADULT. Since this is a prescription product, as a purchaser you agree that the purchase of multiple kits is only intended for the person placing the order, not for any other individual(s).