IgG4 (class-switch IMMUNE TOLERANCE) devastating disease, clinical consequence can be catastrophic with severe organ damage; Primum non nocere a subscriber shared this seminal review paper on IgG4

reminding us that IgG4-related disease (IgG4-RD) can affect nearly any organ and cause masses or inflammatory lesions (Wallace et al.); IgG4-related disease is associated with increased risk of death.

Then why would RFK Jr. and Makary of HHS and FDA and NIH Bhattacharya etc. still allow the mRNA Malone Bourla mRNA vaccine to stay on market? Each new shot is a booster, no? do they not know this? see my prior stack. excellent important paper by Wallace et al. thank you Primum non nocere.

Current and future advances in practice: IgG4-related disease Open Access

Zachary S Wallace ,

Guy Katz ,

Yasmin G Hernandez-Barco ,

Matthew C Baker

https://doi.org/10.1093/rap/rkae020

Abstract

IgG4-related disease (IgG4-RD) is an increasingly recognized cause of fibroinflammatory lesions in patients of diverse racial and ethnic backgrounds and is associated with an increased risk of death. The aetiology of IgG4-RD is incompletely understood, but evidence to date suggests that B and T cells are important players in pathogenesis, both of which are key targets of ongoing drug development programmes. The diagnosis of IgG4-RD requires clinicopathological correlation because there is no highly specific or sensitive test. Glucocorticoids are highly effective, but their use is limited by toxicity, highlighting the need for studies investigating the efficacy of glucocorticoid-sparing agents. B cell-targeted therapies, particularly rituximab, have demonstrated benefit, but no randomized clinical trials have evaluated their efficacy. If untreated or under-treated, IgG4-RD can cause irreversible organ damage, hence close monitoring and consideration for long-term immunosuppression is warranted in certain cases.

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