Is there dose response whereby Higher the Number of Vaccines Previously Received (Malone Bancel mRNA technology based COVID gene shots), Higher Risk of Contracting COVID? Shrestha et al. proved YES!

This is negative efficacy-negative effectiveness (ideal vs real world settings); bottom line for Bhattacharya, Makary, Nesheiwat, Bobby Jr. et al., in case they missed this study by Shrestha et al.

SOURCE:

https://academic.oup.com/ofid/article/10/6/ofad209/7131292

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Shrestha et al.’s study included ‘employees of Cleveland Clinic in employment when the bivalent COVID-19 vaccine first became available.

Among 51 017 employees, COVID-19 occurred in 4424 (8.7%) during the study. In multivariable analysis, the bivalent-vaccinated state was associated with lower risk of COVID-19 during the BA.4/5-dominant (hazard ratio, 0.71 [95% confidence interval, .63–79]) and the BQ-dominant (0.80 [.69–.94]) phases, but decreased risk was not found during the XBB-dominant phase (0.96 [.82–.1.12]). The estimated vaccine effectiveness was 29% (95% confidence interval, 21%–37%), 20% (6%–31%), and 4% (−12% to 18%), during the BA.4/5-, BQ-, and XBB-dominant phases, respectively. The risk of COVID-19 also increased with time since the most recent prior COVID-19 episode and with the number of vaccine doses previously received.’

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You must not wait for another catastrophic crisis (at times manufactured but we are prevented from making our own basic personal decisions or accessing needed drugs and response tools) to catch you off-guard. We must take charge and be prepared today so that we can enjoy peace of mind tomorrow.

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