Jeremy Howick, Ioannidis et al.: "Most healthcare interventions tested are not effective according to high quality evidence: a systematic review and meta-analysis"
Jeremy Howick, Ioannidis et al.: "Most healthcare interventions tested are not effective according to high quality evidence: a systematic review and meta-analysis"
In this large sample of 1567 drugs, interventions studied...effects of most interventions (94%) interventions were not supported by high quality evidence.
Not surprised by the findings. But trusting Cochrane or any medical " authority" is a real problem for me now also. Such a sad situation for us all. I do know that in US the elderly people put on hospice and removed from most of their prescription drugs end up living longer than people who stay on the drugs until the end.
John Ioannidis (Stanford) is considered by many as one of the leading epidemiologists and physician-scientists alive today.
It appears they may have empirically demonstrated a preponderance of the modern public health and institutional medicine health care paradigm is literally founded on shit data fatally lacking sufficient quality to support the policy and presumptions of care being actively promoted by these institutions and their employees.
The Collins/Fauci-era, Big Med and public health institutions we see today need a hostile takeover, radical reorganization and right-sizing. These institutional zombies must die... before they harvest the lives and livelihoods of any more innocent people by fiat of pernicious maladministration and an enabling deviant executive culture that has normalized depraved indifference regarding the industrial monetization of individual human suffering.
The study reflects the fraudulent manipulation of statistics to create the endpoint for profit! The woman’s health initiative that was a $30 million study is a prime example. It was designed to discredit estrogen and push osteoporosis drugs by Lilly. Lilly was smart enough to invite George Bush Senior on to their Board of directors so he could get the federal government to fund the $30 million study. Today Alex Azar from Lilly runs NIH.
Sad to say, but true. For example: When assessing patients, their med lists are a hodgepodge of one side effect after another. Most medications can cause the disease signs and symptoms they are treating. It takes much detailed time and attention to figure it out. With burn out and staff shortages, who will even notice? And of course, one specialist will not side step another. As a patient, I make it simple, I just say no to drugs.
Dr Alexander -It’s an interesting quote about Cochrane and GRADE being limits since they are as close to true standards for EBM appraisal as we have in this fallen world — based on method and less on performance in past decade for Cochrane. Cochrane methods are evolved tools and the problem of their contribution is performance corruption— yet in the abstract you quoted, Cochrane can actually be seen doing its job — showing the washout of claims for therapies that are ineffective or unproven. Did I read this correctly? We need to have some tools that are truly audited and rigorously policed by editors and guideline orgs — and we need Professor Ionnidis to continue to make deep theoretical criticism of these gold standards and assumptions!! Too often some standards may be lauded beyond their scope of merit because physicians must have something to help them make decisions. It’s like our US jury system — flawed and needing aid, but all we have. Sadly, vaccines were the cause of a great rift in 2016 between the main body of the collaborative and one of the Danish founders! Dr Gotzsche was persecuted in many ways for sounding the alarm on an SR for vaccine. This news link is for names and details only and not any interpretations of the facts.
Not surprised by the findings. But trusting Cochrane or any medical " authority" is a real problem for me now also. Such a sad situation for us all. I do know that in US the elderly people put on hospice and removed from most of their prescription drugs end up living longer than people who stay on the drugs until the end.
What a gutsy thing to publish.
John Ioannidis (Stanford) is considered by many as one of the leading epidemiologists and physician-scientists alive today.
It appears they may have empirically demonstrated a preponderance of the modern public health and institutional medicine health care paradigm is literally founded on shit data fatally lacking sufficient quality to support the policy and presumptions of care being actively promoted by these institutions and their employees.
The Collins/Fauci-era, Big Med and public health institutions we see today need a hostile takeover, radical reorganization and right-sizing. These institutional zombies must die... before they harvest the lives and livelihoods of any more innocent people by fiat of pernicious maladministration and an enabling deviant executive culture that has normalized depraved indifference regarding the industrial monetization of individual human suffering.
The study reflects the fraudulent manipulation of statistics to create the endpoint for profit! The woman’s health initiative that was a $30 million study is a prime example. It was designed to discredit estrogen and push osteoporosis drugs by Lilly. Lilly was smart enough to invite George Bush Senior on to their Board of directors so he could get the federal government to fund the $30 million study. Today Alex Azar from Lilly runs NIH.
Sad to say, but true. For example: When assessing patients, their med lists are a hodgepodge of one side effect after another. Most medications can cause the disease signs and symptoms they are treating. It takes much detailed time and attention to figure it out. With burn out and staff shortages, who will even notice? And of course, one specialist will not side step another. As a patient, I make it simple, I just say no to drugs.
Dr Alexander -It’s an interesting quote about Cochrane and GRADE being limits since they are as close to true standards for EBM appraisal as we have in this fallen world — based on method and less on performance in past decade for Cochrane. Cochrane methods are evolved tools and the problem of their contribution is performance corruption— yet in the abstract you quoted, Cochrane can actually be seen doing its job — showing the washout of claims for therapies that are ineffective or unproven. Did I read this correctly? We need to have some tools that are truly audited and rigorously policed by editors and guideline orgs — and we need Professor Ionnidis to continue to make deep theoretical criticism of these gold standards and assumptions!! Too often some standards may be lauded beyond their scope of merit because physicians must have something to help them make decisions. It’s like our US jury system — flawed and needing aid, but all we have. Sadly, vaccines were the cause of a great rift in 2016 between the main body of the collaborative and one of the Danish founders! Dr Gotzsche was persecuted in many ways for sounding the alarm on an SR for vaccine. This news link is for names and details only and not any interpretations of the facts.
https://www.statnews.com/2018/09/16/expulsion-cochrane-peter-gotzsche-medicine/
I would love to see which drugs were deemed effective, which were not, and which were dangerous...