Mishra & Banerjea: "SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia"; that SARS-CoV-2 gene product, Spike, is able to modify the host exosomal cargo, which
gets transported to distant uninfected tissues and organs and can initiate a catastrophic immune cascade within within Central Nervous System (CNS)." SARS-CoV-2 mediated neurological CNS damage
In simple, cells exposed to COVID virus go on to release exosomes that carry spike protein and micro RNAs that become part of a devastating neurological sequelae. Note that as viral infection unfolds, the host cells go on to release exosomes and other extra-cellular vesicles that transport viral and host components which can modulate the immune response. The spike and microRNAs are part of this transport and are having catastrophic consequences. The key is the modulation of the immune response. Moreover, this exosomal transport pathway occurs across the body, and not just in the nervous system and we are cueing you towards not just due to natural exposure infection but due to the consequence of COVID gene injection vaccine. This is the core argument in this substack I wish you to focus on and which is that end-stage serious illness COVID symptoms are mimicked via the COVID gene injection. And remember we are also writing on the role of these extra-cellular vesicles and exosomes as they get into the vagus nerve which then creates a host of serious complications system wide given the multitude of connections the vagus nerve has to many tissues and organs etc. (especially the brain) across the body.
We are learning daily how this COVID gene injection is deadly and stand by us as we move to inform you and those willing to read and listen.
SOURCE:
https://pubmed.ncbi.nlm.nih.gov/33936086/
doi: 10.3389/fimmu.2021.656700.eCollection 2021.
‘SARS-CoV-2 Spike transfected cells release a significant amount of exosomes loaded with microRNAs such as miR-148a and miR-590. microRNAs gets internalized by human microglia and suppress target gene expression of USP33 (Ubiquitin Specific peptidase 33) and downstream IRF9 levels. Cellular levels of USP33 regulate the turnover time of IRF9 via deubiquitylation….
Our results also demonstrate that absorption of modified exosomes effectively regulate the major pro-inflammatory gene expression profile of TNFα, NF-κB and IFN-β. These results uncover a bystander pathway of SARS-CoV-2 mediated CNS damage through hyperactivation of human microglia. Our results also attempt to explain the extra-pulmonary dysfunctions observed in COVID-19 cases when active replication of virus is not supported. Since Spike gene and mRNAs have been extensively picked up for vaccine development; the knowledge of host immune response against spike gene and protein holds a great significance.’
Dear Readers,
I also embed this short piece on The Wellness Company and The UNITY Project.
First, The Wellness Company.
I am proud to announce a unique partnership with The Wellness Company and everyone who believes in medical freedom. My dear and esteemed colleagues Dr. Peter McCullough and Dr. Harvey Risch are also in partnership with The Wellness Company which provides telemedicine services for long-haul COVID, vaccine injury, and medical exemptions along with supplements and products that are fully aligned with our values. This support for The Wellness Company stems from the sub-optimal medical care and response that we experienced throughout the pandemic. It became apparent that there are many glaring gaps in our healthcare system and people were not properly treated. Thus, the pivot by us to support The Wellness Company. Take a stand against a broken healthcare delivery system with a membership in The Wellness Company, which directly funds our fight against medical tyranny. Click here The Wellness Company for more information.
I also provide scientific support to The UNITY Project out of California. A magical organization for good. I support this tremendous initiative with some fine colleagues who have been warriors in the fight against all the wrongs in COVID. The UNITY Project aligns with my core values for it is very fierce in its fight to protect children from the danger of the largely safety untested COVID gene injection (The Unity Project Formed by Concerned Parents to Coordinate Opposition to California's K-12 COVID-19 Vaccination Mandate) (contact: info@theunityproject.org)
Please consider ordering my book ‘Presidential Takedown’:
Order via this LINK
The Bio weapon jab is a high tech version of Fauci's patented HIV-Aids. There's an explosion of cancer, strokes, heart attacks , neurological damage.... et al.
Does anyone think that IV nutrition would help with the poison of the death shot vaccine? My 81 year old husband did not take the shot but he was sick in September bad cold spitting up mucus and tested positive for covid. We had the flcc. Meds on hand and used but he was very tired after and we got IV nutrients and extra vitamin C helped a lot.