mRNA COVID vaccines & K. Acevedo-Whitehouse: Acevedo was PUNISHING on the lack of effectiveness, lack of safety studies, harms, & deaths accumulated around the mRNA technology platform
Abstract is stunningly clear about the deceit & fraud by FDA, phama such as Pfizer & Moderna: there are no published studies on the biodistribution, cellular uptake, endosomal escape, translation rate
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876036/
‘To date, there are no published studies on the biodistribution, cellular uptake, endosomal escape, translation rates, functional half-life and inactivation kinetics of synthetic mRNA, rates and duration of vaccine-induced antigen expression in different cell types.
Furthermore, despite the assumption that there is no possibility of genomic integration of therapeutic synthetic mRNA, only one recent study has examined interactions between vaccine mRNA and the genome of transfected cells, and reported that an endogenous retrotransposon, LINE-1 is unsilenced following mRNA entry to the cell, leading to reverse transcription of full length vaccine mRNA sequences, and nuclear entry.
This finding should be a major safety concern, given the possibility of synthetic mRNA-driven epigenetic and genomic modifications arising.
We propose that in susceptible individuals, cytosolic clearance of nucleotide modified synthetic (nms-mRNAs) is impeded. Sustained presence of nms-mRNA in the cytoplasm deregulates and activates endogenous transposable elements (TEs), causing some of the mRNA copies to be reverse transcribed. The cytosolic accumulation of the nms-mRNA and the reverse transcribed cDNA molecules activates RNA and DNA sensory pathways. Their concurrent activation initiates a synchronized innate response against non-self nucleic acids, prompting type-I interferon and pro-inflammatory cytokine production which, if unregulated, leads to autoinflammatory and autoimmune conditions, while activated TEs increase the risk of insertional mutagenesis of the reverse transcribed molecules, which can disrupt coding regions, enhance the risk of mutations in tumour suppressor genes, and lead to sustained DNA damage.
Susceptible individuals would then expectedly have an increased risk of DNA damage, chronic autoinflammation, autoimmunity and cancer. In light of the current mass administration of nms-mRNA vaccines, it is essential and urgent to fully understand the intracellular cascades initiated by cellular uptake of synthetic mRNA and the consequences of these molecular events.’
Acevedo-Whitehouse K, Bruno R. Potential health risks of mRNA-based vaccine therapy: A hypothesis. Med Hypotheses. 2023 Feb;171:111015. doi: 10.1016/j.mehy.2023.111015. Epub 2023 Jan 25. PMID: 36718314; PMCID: PMC9876036.
This “technology” had promise to cure, no doubt. However, it needed a hell of a lot more study and investigation into how it functioned in vivo before being let loose on the masses. Now, I think it is dead as a treatment method for decades because of the harm this mRNA techno has done worldwide. Those accountable must be brought before a competent court, and if convicted pay the ultimate price for the death and destruction done. #NoAmnesty #NoQuarter #NeverForget #DoNotComply
"If our hypothesis were to be confirmed, the implications for public health would be staggering and appalling in the context of the mass-scale COVID-19 vaccination already taking place, particularly if the nms-mRNA enters brain [82], bone marrow [84], and – if already present in the vaccinee – cancerous or pre-cancerous cells [143], or if the vaccine is administered to females early in their pregnancy and the nms-mRNA transfects embryonic cells [77]."
" ... parts of the SARS-CoV-2 genome could be undergoing reverse-transcription and genomic integration within infected somatic cells, leading to persistent transcription of the integrated sequences. A recent paper confirmed this hypothesis by an in vitro study that detected the presence of reverse-transcribed copies of SARS-CoV-2 sequences in transfected human cells, and by finding active transcription of the integrated subgenomic SARS-CoV-2 segments [60]."
If these researchers could generate this hypothesis, why couldn't the FDA? Why was this hypothesis not conceived and tested prior to mass vaccination and publication of this paper?
There are no excuses. Heads must roll!