Nattokinase in 2015 was showing us its anti-coagulation/fibrinolysis capacity: 'A single-dose (2,000 FU NK) of oral nattokinase potentiates thrombolysis and anti-coagulation profiles; in other words,

dissolves clots!; D-dimer concentrations elevated significantly! a single-dose of NK administration appears enhancing fibrinolysis and anti-coagulation via several different pathways simultaneously.

SOURCE:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479826/

‘A double-blind, placebo-controlled cross-over NK intervention study was carried out in 12 healthy young males. Following the baseline blood draw, each subject was randomized to receive either a single-dose of 2,000 FU NK (NSK-SD, Japan Bio Science Laboratory Co., Ltd) or placebo with subsequent cross-over of the groups. Subjects donated blood samples at 2, 4, 6 and 8 hours following administration for analysis of coagulation/fibrinolysis parameters.

As a result, D-dimer concentrations at 6, and 8 hours, and blood fibrin/fibrinogen degradation products at 4 hours after NK administration elevated significantly (p < 0.05, respectively). Factor VIII activity declined at 4 and 6 hours (p < 0.05, respectively), blood antithrombin concentration was higher at 2 and 4 hours (p < 0.05, respectively), and the activated partial thromboplastin time prolonged significantly at 2 and 4 hours following NK administration (p < 0.05 and p < 0.01, respectively).

All the changes, however, were within the normal range. In conclusion, thus, a single-dose of NK administration appears enhancing fibrinolysis and anti-coagulation via several different pathways simultaneously.’