NATTOKINASE (NK) shown to be effective: Chen et al. shows effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants

Chen et al. shows how effective NK is and proposes NK at a dose of 10,800 FU/day, beyond the present 2000 FU (or 4000 FU/day); Chen concludes that lower doses are ineffective & to be revisited

https://pubmed.ncbi.nlm.nih.gov/36072877/

‘study involving 1,062 participants…objective was to examine the efficacy of NK in atherosclerosis and hyperlipidemia and safety at the dose of 10,800 FU/day after 12 months of oral administration.

Various factors, including lower doses that influence NK pharmacological actions, were also investigated…

found that NK at a dose of 10,800 FU/day effectively managed the progression of atherosclerosis and hyperlipidemia with a significant improvement in the lipid profile.

A significant reduction in the thickness of the carotid artery intima-media and the size of the carotid plaque was observed.

The improvement rates ranged from 66.5 to 95.4%.

NK was found to be ineffective in lowering lipids and suppressing atherosclerosis progression at a dose of 3,600 FU/day.

The lipid-lowering effect of NK was more prominent in subjects who smoked, drank alcohol, and subjects with higher BMI. Regular exercise further improved the effects of NK.

Co-administration of vitamin K2 and aspirin with NK produced a synergetic effect. No noticeable adverse effects associated with the use of NK were recorded.

data demonstrate that atherosclerosis progression and hyperlipidemia can be effectively managed with NK at a dose of 10,800 FU/day. The lower dose of 3,600 FU per day is ineffective.

The dose of 10,800 FU/day is safe and well tolerated. Some lifestyle factors and the coadministration of vitamin K2 and aspirin lead to improved outcomes in the use of NK. Our findings provide clinical evidence on the effective dose of NK in the management of cardiovascular disease and challenge the recommended dose of 2,000 FU per day.’