Of low testosterone in males & COVID: "Association of Male Hypogonadism With Risk of Hospitalization for COVID-19"; now well established that a low testosterone concentration is a marker severe COVID
Dhindsa: study suggests that men with hypogonadism are more likely to be hospitalized after COVID-19 infection compared with men with eugonadism and men receiving adequate testosterone therapy.
Male hypogonadism is a condition in which the body doesn't produce enough of the hormone that plays a key role in masculine growth and development during puberty (testosterone) or enough sperm or both.
https://www.mayoclinic.org/diseases-conditions/male-hypogonadism/symptoms-causes/syc-20354881
‘The COVID-19 pandemic has exacted a heavy toll on public health. Epidemiologic data have identified certain characteristics that are associated with adverse outcomes, including advanced age, obesity, and systemic diseases, particularly diabetes, hypertension, chronic lung disease, and cardiovascular and cerebrovascular diseases.1 In addition, patients hospitalized for COVID-19 are more likely to be men than women.2 Therefore, it was presumed that testosterone is a risk factor for severe COVID-19 and that estrogen may be protective against COVID-19.3
However, not all men have similar testosterone concentrations.4,5 Men’s testosterone concentrations decrease continuously by 1% to 2% per year, starting after the third decade of life.6-8 In addition, obesity, metabolic syndrome, and chronic illnesses, such as type 2 diabetes, kidney insufficiency, and chronic lung disease, are associated with lower serum testosterone concentrations among men.4,9,10 Thus, aging and the presence of comorbid conditions, which are risk factors for hospitalization for COVID-19, are also associated with hypogonadism, which raises the question of whether hypogonadism is a risk factor for COVID-19–related hospitalization among men.’
‘Question Is male hypogonadism (low testosterone levels) a risk factor for hospitalization for COVID-19?
Findings In this cohort study of 723 men, those with hypogonadism had significantly higher odds than men with eugonadism of being hospitalized, independent of other known risk factors for COVID-19–related hospitalization. Men receiving testosterone therapy had a similar risk of hospitalization as men with eugonadism.
Meaning This study suggests that men with hypogonadism are more likely to be hospitalized after COVID-19 infection compared with men with eugonadism and men receiving adequate testosterone therapy.’
Overall, this one study is important in terms of findings and adds another layer. Yet cannot be definitive without further examination. Moreover, it goes against (argues against) research by Goren et al. (Anti‐androgens may protect against severe COVID‐19 outcomes: results from a prospective cohort study of 77 hospitalized men) which shows that anti‐androgens could represent a “promising treatment modality for COVID‐19”.
There is also work by Toscano-Guerra et al. looking at the recovery of serum testosterone levels as a predictor of survival from COVID-19 in male patients. Results support a “significant role of testosterone status in the immune responses to COVID-19”. The findings “warrant future experimental explorations of mechanistic relationships between testosterone status and SARS-CoV-2 infection outcomes, with potential prophylactic or therapeutic implications.”
The reader should bear these conflicting results in mind.
This illuminates another issue, the inability of modern municipal water purification systems to remove pharmaceuticals and estrogen from the drinking water supply.
How many hormones and pro hormones are being ingested by young (lighter weight small persons) and what is the effect of that higher dose on our young and their hormonal development as both prepubescent and juveniles moving through puberty?
Fact. Such systemic, chronic exposure to hormonal concentrations and pharmaceutical toxins in potable water consumed by children and juveniles is unprecedented.
By that I mean... unprecedented in the history of human evolutionary biology.
Never before has such a biologically active and biologically timely concentration of dose exposures been distributed to children and juveniles in such a systematic and consistent manner.
These issues concern the hardy, persistent molecules often resistant to deactivation or filtration.
The result of this unprecedented dosing of children and juveniles cannot be benign.
Is this at root of some what we see behaviorally expressed today?f
All this is courtesy of our Municipal, Country, State, Federal and Academic Public Health Professionals and university colleagues.
Whatever happened to "First of all things, do no harm."
How did that become "First of all things, take the money."
This institutional culture, academically and operationally, has been taking money to do terrible things to children and their parents for many decades.
They are the Tuskegee Experiment. This is who they are and who they have always been.
We are tragicomically naive to think for a moment they are institutionally capable of having a child's best interests at heart. A child is merely a device to pursue future funding. A child is merely an exploitable institutional resource for sustainable funding.
Sadly, our education bureaucracy is just as bad.
Rendering children into money and making families pay for it. That is the legacy of public health and compulsory schooling in the United States.
Why are surprised that COVID is what it is?
Could male hypogonadism also be associated with post-vaccination injury too?