Risking IN UTERO development of the baby via the mRNA (Pfizer, Moderna) vaccinated mother? Yes! Zurlo et al. reports "The anti-SARS-CoV-2 Pfizer vaccine suppresses mithramycin-induced erythroid

differentiation & expression of embryo-fetal globin genes in human erythroleukemia K562 cells"; increased concentrations of Pfizer vaccine sharply inhibits the expression of embryo-fetal globin genes"

https://www.biorxiv.org/content/10.1101/2023.09.07.556634v1

Researchers found that the Pfizer ‘BNT162b2 vaccine suppresses mithramycin-induced erythroid differentiation of K562 cells. Reverse-transcription-PCR and Western blotting assays demonstrated that suppression of erythroid differentiation was associated with sharp inhibition of the expression of α-globin and γ-globin mRNA accumulation. Inhibition of accumulation of ζ-globin and ε-globin mRNAs was also observed. In addition, we provide in silico studies suggesting a direct interaction between SARS-CoV-2 Spike protein and Hb Portland, that is the major hemoglobin produced by K562 cells.’

Sonia Elijah (please support her) did some very good scholarship on this issue also and writes (above, below):

Pfizer-BioNTech COVID-19 vaccine sharply inhibits accumulation of embryo-fetal globin mRNAs

‘They found that increased concentrations of the BNT162b2 vaccine sharply inhibits the expression of embryo-fetal globin genes in K562 cells.

“The BNT162b2 vaccine suppresses mithramycin-induced erythroid differentiation of K562 cells. Reverse-transcription-PCR and Western blotting assays demonstrated that suppression of erythroid differentiation was associated with sharp inhibition of the expression of α-globin and γ-globin mRNA accumulation. Inhibition of accumulation of ζ-globin and ε-globin mRNAs was also observed.”’

Sonia further reports:

‘Fetal hemoglobin (Hb F) is a principal oxygen carrier in both preterm and term neonates. A tetramer of two alpha- and two gamma-globin chains make up the fetal hemoglobin molecule. Around birth, expression of gamma-globin is progressively silenced and beta-globin expression is activated. Fetal hemoglobin has a significantly higher affinity for oxygen than adult hemoglobin.

Human K562 cells are bone marrow stem cells isolated from a 53-year-old chronic myelogenous leukemia patient. The K562 cell line is widely used in immunology and immune system disorder research.

The researchers chose to use the human K562 cell line for the following reasons:

• It is studied as a model system mimicking some steps of erythropoiesis. (Erythropoiesis is the human body’s process of making red blood cells.)

• They express baseline levels of globin genes, the most important being those coding the embryo-fetal a-, z-, e- and g-globins.

• Fetal hemoglobin (Hb F) are also produced by K562 cells.

• K562 cells have been used as a model system to study the regulation

  of the expression of embryo-fetal globin genes.

The researchers found that as the concentration of the vaccine was increased, proliferation of bone marrow stem cells was significantly inhibited. (Figure A)

Source: Zurlo et al. September 2023 study’