Spike protein from COVID virus (& we extrapolate direct from mRNA technology based vaccine) S1 & Trimer both induced mitochondrial damage including functional deficits in mitochondrial respiration

'Spike Proteins of SARS-CoV-2 Induce Pathological Changes in Molecular Delivery and Metabolic Function in the Brain Endothelial Cells'; Kim et al.

‘First, we identified rapid internalization of the receptor-binding domain (RBD) S1 domain (S1) and active trimer (Trimer) of SARS-CoV-2 spike protein through ACE2 in brain ECs. Moreover, internalized S1 increased Rab5, an early endosomal marker while Trimer decreased Rab5 in the brain ECs. Similarly, the permeability of transferrin and dextran was increased in S1 treatment but decreased in Trimer, respectively. Furthermore, S1 and Trimer both induced mitochondrial damage including functional deficits in mitochondrial respiration.’

SOURCE:

https://www.mdpi.com/1999-4915/13/10/2021/htm