Did Nakahara in human cardiac study show that positron emission tomography (PET) scans of heart had changes in near all who took mRNA vaccine? with changes in cardiac metabolism at least 6 months or >

Yes; Compared to nonvaccinated patients, asymptomatic patients who received their 2nd vaccination 1-180 days prior to imaging showed increased myocardial FDG uptake on PET/CT.’ McCullough

https://pubmed.ncbi.nlm.nih.gov/37724969/

Radiology. 2023 Sep;308(3):e230743.

doi: 10.1148/radiol.230743.

‘Patients who developed myocarditis following SARS-CoV-2 vaccination show abnormalities on cardiac MRI. However, whether myocardial changes occur in asymptomatic individuals following vaccination is not well established.

Purpose To assess myocardial ¹⁸Fluorine-fluorodeoxyglucose (¹⁸F-FDG) uptake on PET/CT in asymptomatic SARS-CoV-2 vaccinated patients compared to nonvaccinated patients. Materials and Methods This retrospective study included patients who underwent ¹⁸F-FDG PET/CT for indications unrelated to myocarditis during the period before (11/1/2020 - 2/16/2021) and after (2/17/20121 - 3/31/2022) SARS-CoV-2 vaccines were available.

Myocardial and axillary FDG uptake were quantitatively assessed using maximum standardized uptake value (SUVmax).

SUVmax values in all patients and in patients stratified by sex (male/female), age (<40, 41-60, >60 years), and time interval between vaccination and PET/CT were compared using Mann-Whitney U test or Kruskal-Wallis test with post ad -hoc Dwass, Steel, Critchlow-Fligner multiple comparison analysis. Results The study included 303 nonvaccinated patients (mean age, 52.9 years ± 14.9 [SD]; 157 females) and 700 vaccinated patients (mean age, 56.8 years ± 13.7 [SD]; 344 females).

Vaccinated patients had overall higher myocardial FDG uptake compared to nonvaccinated patients (median SUVmax, 4.8 [IQR: 3.0-8.5] vs median SUVmax, 3.3 [IQR: 2.5-6.2]; P < .0001). Myocardial SUVmax was higher in vaccinated patients regardless of sex (median range, 4.7-4.9 [IQR: 2.9-8.6]) or patient age (median range, 4.7-5.6 [IQR: 2.9-8.6]) compared to corresponding nonvaccinated groups (sex median range, 3.2-3.9 [IQR: 2.4-7.2]; age median range, 3.3-3.3 [IQR: 2.3-6.1]; P range, <.001-.015). Furthermore, increased myocardial FDG uptake was observed in patients imaged 1-30, 31-60, 61-120, and 121-180 days after their second vaccination (median SUVmax range, 4.6-5.1 [IQR: 2.9-8.6]) and increased ipsilateral axillary uptake was observed in patients imaged 1-30, 31-60, 61-120 days after their 2nd vaccination (median SUVmax range, 1.5-2.0 [IQR: 1.2-3.4]) compared to the nonvaccinated patients (P range, <.001-<.001).

Conclusion Compared to nonvaccinated patients, asymptomatic patients who received their 2nd vaccination 1-180 days prior to imaging showed increased myocardial FDG uptake on PET/CT.’

https://pubmed.ncbi.nlm.nih.gov/37724969/

‘In this observational study of patients who underwent PET/CT during comprehensive medical check-ups or to evaluate malignancies, patients who had received a SARS-CoV-2 mRNA-based vaccine showed increased myocardial ¹⁸F-FDG uptake on scans compared with nonvaccinated patients (median visual score, 2 [IQR, 0–3] vs 1 [IQR, 0–2]; P < .001; median SUV_max, 4.75 g/mL [IQR, 3.0–8.5 g/mL] vs 3.3 g/mL [IQR, 2.5–6.2 g/mL]; P < .001). This increase in myocardial ¹⁸F-FDG uptake in vaccinated patients was also observed in subgroup analyses that excluded individuals with cancer or homogeneous myocardial uptake.’