It is my understanding that they used the pseudouridine because it:
“It is demonstrated that Ψ can enhance RNA stability and, in the meantime, decrease anti-RNA immune response (Karikó et al., 2008)”
Beyond this, are there studies that show the safety of using pseudouridine long them. I didn’t see any.
The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines
frontiersin.org/article…
https://www.frontiersin.org/articles/10.3389/fcell.2021.789427/full
Thanks for this.
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It is my understanding that they used the pseudouridine because it:
“It is demonstrated that Ψ can enhance RNA stability and, in the meantime, decrease anti-RNA immune response (Karikó et al., 2008)”
Beyond this, are there studies that show the safety of using pseudouridine long them. I didn’t see any.
The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines
https://www.frontiersin.org/articles/10.3389/fcell.2021.789427/full
Thanks for this.