If we were seeking to take a very harmless virus that causes self-limiting infection or diseases (so it is non-noxious) and to then convert it (transform it) into a devastating biological weapon that could inflict mass casualties and destruction, then the approach would be simple and would be similar to the approach being used today in the US and other nations: we would continue mass population vaccination with a sub-optimal ‘leaky’ vaccine and suboptimal population-level immune pressure while within an ongoing pandemic with pathogen all around circulating, exerting tremendous infectious pressure, as is the case now.