I wrote this stack about the fact that the injected mRNA technology gene-based vaccine (Bourla, Bancel, Malone etc.) could have NEVER worked (besides it being deadly as we know) e.g. systemic
I wrote this stack about the fact that the injected mRNA technology gene-based vaccine (Bourla, Bancel, Malone etc.) could have NEVER worked (besides it being deadly as we know) e.g. systemic
bloodstream (& lymph) circulating IgG & secretory IgA cannot protect the upper airways (or lower RT) or the respiratory mucosal layer where pathogen resides; see exchange with Dr. Mike Yeadon & me
Dr. Yeadon gave us a classroom here in lay language and short and sweet…I felt it is worth sharing as a standalone stack so that Dr. Yeadon’s input is not lost in comments, it is so critical…
see my input and his for I think the exchange is a teaching moment…sometimes life hands you a high lesson, IMO Yeadon gave us one here…I go direct to the comments…It was initially provoked by a subscriber asking me how come Vanden Bossche has not stated this…well, IMO he has in various way, his focus always has been on the evolutionary dance between virus (virus infectious pressure) & population immunity )mounting immune response) and thus the two entities exerting bi-directional pressure on each other and the population level immunity is MOUNTING and not fully ‘mature’ not arriving yet at its maximal binding affinity for the target antigen…this results in sub-optimal immune pressure on the spike (again, if you accept the COVID narrative, I am explaining Geert’s core thesis) and thus resulting Darwinian natural selection pressure causing the selection of more infectious sub-variants/clades over time…
to this effect…
key argument being:
A key aspect of this functional separation between mucosal and systemic immunity concerns the nature of antibodies produced by plasma cells located directly beneath the mucous membranes. These antibodies—secretory immunoglobulin A (sIgA)—are secreted across the mucous membranes to their surface. They are thus on site to meet airborne viruses, and they may be able to prevent them from binding and infecting the cells within those mucous membranes. The same mode of protection pertains to the digestive tract as well.
In contrast, IgG and circulating IgA are the main antibodies found in the bloodstream. They cannot prevent the entry of viruses into the cells that line the airways or the gut, and they may at best counteract their spread if they gain entry to the circulation. Crucially, vaccines that are injected into the muscle—i.e., the interior of the body—will only induce IgG and circulating IgA, but not secretory IgA. The antibodies induced by such vaccines therefore cannot and will not effectively protect the cells of the respiratory tract against infection by airborne viruses [1,2].’
start seeing the comment exchange between Yeadon and I from here as I think Yeadon gave an actual classroom lecture…
2 hrs agoAuthor
Secretory IgA (sIgA) in the Mucosal Immune System is the key antibody (immunoglobulin) involved in the immune response in the respiratory mucosa.
Paul, I agree completely with your LOGIC. Those who still believe in & accept the official narrative of how acute respiratory illnesses are caused (as I, too, used to until quite recently) must now recognise that they have been lied to, systematically, wholesale, for decades, about “vaccines” against such illnesses.
I have written exactly as you’ve done here, many times in the past (when I still accepted the dominant narrative). I knew that an injection of foreign material, often called the antigen or immunogen, into the arm or shoulder, must either stay put, or else circulate around the body, simply by diffusing away from the injection site and into blood or lymph. What happens next is that your immune system detects that something that’s not meant to be in your body is indeed inside you. That non-self detection system is exquisitely sensitive and selective. Unless there’s a disease state termed autoimmunity in the injected person, they will never raise an immune response against your own body. But your body will readily respond to invasion by non-self or foreign material; it has no choice, it’s axiomatic.
Depending upon the nature of the foreign material, your body may elaborate a powerful, immune response in the form of antibodies. It generally also causes a “cell-based immune response”, in which mature & highly specific T-cells are multiplied that specifically & sensitively respond in the future by attacking & destroying any cells & tissue that “display” that foreign material.
This will be true of these very “vaccines”. If a person allows themselves to be injected with for example an mRNA-based product, every cell that takes it up is caused to synthesise whatever is encoded by the mRNA sequence. It doesn’t much matter what is encoded. Even if it’s a meaningless polypeptide or protein, it’ll still prompt your body to attack & kill these cells, because it detects you’ve been invaded.
There are several other ways in which these injections must & do result in harms, from subclinical responses all the way to death. It’s not an accident. Way too many obvious reasons why harms will be caused by these injections tells us that. For example, selecting lipid nanoparticle formulations ensures that the injected material will travel everywhere through the body, but will also ensure that substantial amounts of it will accumulate in the ovaries. This too isn’t accidental. This property was well known about long before this era to accumulate in ovaries.
These injections masquerading as “vaccines” been carefully designed to injure, kill and reduce fertility in survivors. Everybody must be told this. Again, not too complicated to understand. The biggest hurdle is that many people “know” that “our government would never deliberately harm us, it’s a ludicrous notion”.
In case some people don’t think that our bodies are equipped with these miraculous immunological mechanisms, consider a real example of such a phenomenon. We know what so easily happens if you don’t get a very good match to your own body before undergoing an organ transplantation procedure, such as a kidney transplant. Your body recognises the foreign tissue & initiates a “host vs graft” response that destroys the “new” kidney. We’ve all heard of transplant rejection & this is why & how it happens. If you have a kidney from a closely-matched person, your body will probably tolerate it.
Back to the antibody response. Antibodies raised in response to a foreign invasion of materials found in blood will themselves only circulate in the blood. These antibodies are of such a large size, compared with most biochemical materials, that they cannot readily even leave the blood vessels, because they are too large to pass through the tiny pores in the walls of such blood vessels. So they definitely CANNOT reach the inside surfaces of your lungs. Even theoretically, they are therefore not capable of defending the “vaccinated” person, and this proves we’re being lied to. If you suspected nothing else, you’d be right to be skeptical of a so-called injected “vaccine” because, by design, it cannot perform as advertised.
What the injected material (the purported “vaccine”) can never do is land on the inner surface of the airways, which extend from nasal passages right down to the gas exchange regions of the deep lung. As you say. It’s correctly described as the mucosal surface. It is at this anatomical location that the body interacts with the outside world, it’s environment and everything in it.
As you’ll probably have heard, I no longer accept the dominant narrative about “respiratory viruses” as the prime cause of acute respiratory illnesses. Bottom line, these illnesses are not infectious in nature and consequently not contagious. No “spreading” or “infecting” people around you simply doesn’t happen. In my opinion, there is no “covid19”, no “SARS-CoV-2 virus” (or indeed any other virus: no virus has scientifically proven to exist).
The entire episode since early 2020 has been a lie, a PHEIC’d (faked ) “pandemic”. Obviously if there’s no pandemic, no public health emergency, no “covid19”, why in the world would anybody even consider a “vaccine”? Why would anyone with the slightest knowledge of pharmaceutical R&D believe for a second believe that a complex biological product could be invented, researched, developed, formulated, manufactured and authorised in under a year?
Your central point is that an injected “vaccine” could not possibly accomplish its primary purpose. The biological response initiated by “vaccination” does not & never could have protected any recipient. I agree. Everyone should know this. It’s very easily grasped. It’s also true imo that, by design, anyone receiving these gene-based injections is at risk of injury and even death. Imposing these ghastly injections when there’s no possibility of an upside, no need to do it anyway, because there’s nothing new to be defended against, no need to restrict our freedoms of movement and other restrictions, surely tells even the most uninformed person that humanity itself is under attack.
We are surrounded entirely by lies. Accept nothing official automatically. Always think through the underlying motivations behind whatever you’re being told and “sold”.
27 mins agoAuthor
I agree fully that the lipid nanoparticle platform is and was a dangerous as the mRNA technology itself. together they are catastrophic. it is as if we put something into us that was NOT needed that did us grave harm and likely lifelong. and I believe THEY knew. those involved. it is very sinister and you have been warning.
25 mins agoAuthor
and now I am seeing a disturbing SILENCE...have you noticed? as if those on our side who were in the battle are somehow shifting...they smell money...look, let me be frank, some of these characters we have been dealing with and fighting side by side with over time I have come to learn money is more important...if today they can find a way to tell the population that mRNA is good, and they can get a cut of the pie, they would!
just nowAuthor
if they could get some of Malone's and Fauci's and Francis Collins and Weissman's etc. patent money etc., they would switch sides. anything to turn to the donors and beg for money.
48 mins agoAuthor
oh My God, for you Dr. Yeadon to agree with me is staggering...I place you among the best, the top and well you know that. I am one of the dissidents like you who are so very sidelined. your work is seminal...and I think because you are so out of the box yet ahead of the curve, they envy you and despise you because they cannot logically debate you. I find I must read daily everything I could to try to make sense of all this madness for madness it is and IMO, all of what you have said day 1 turned out and is true. and in my basic understanding of immunology and virology relative to say yourself, I still argue that intramuscular vaccines (like the one folk got for COVID fraud) that induces serum antibodies (IgG and circulating IgA) and not secretory IgA (in the mucus cells of the respiratory tract) cannot protect the upper airways (respiratory mucosal layer) where the virus lands. This entire COVID gene injection was a lie, all aspects of it. IMO.
46 mins agoAuthor
huge praise Sir for all you have done and the leadership you have shown and the grace under pressure. You are unwavering and it speaks a tremendous lot. We have all benefitted from you even those who refuse to acknowledge the monumental role you have played.
38 mins agoAuthor
I have read your response in full and while I am honored you would agree, your text book near class room explanation is like a high level academic one and the readers here are benefitting from one of the world's most brilliant minds in what we faced in COVID, you lead vaccine development for Pfizer, you are the world's expert, and you are handing us a high lesson here...I hope people take time to read these comments. It is as close to the money as we can come in as lay a language as we could go. I/we are very grateful to you Dr. Yeadon, a real warrior and hero to me and many. I speak for them.
45 mins agoAuthor
A key aspect of this functional separation between mucosal and systemic immunity concerns the nature of antibodies produced by plasma cells located directly beneath the mucous membranes. These antibodies—secretory immunoglobulin A (sIgA)—are secreted across the mucous membranes to their surface. They are thus on site to meet airborne viruses, and they may be able to prevent them from binding and infecting the cells within those mucous membranes. The same mode of protection pertains to the digestive tract as well.
In contrast, IgG and circulating IgA are the main antibodies found in the bloodstream. They cannot prevent the entry of viruses into the cells that line the airways or the gut, and they may at best counteract their spread if they gain entry to the circulation. Crucially, vaccines that are injected into the muscle—i.e., the interior of the body—will only induce IgG and circulating IgA, but not secretory IgA. The antibodies induced by such vaccines therefore cannot and will not effectively protect the cells of the respiratory tract against infection by airborne viruses [1,2]. This realization is neither contentious nor new. As long as 30 years ago, McGhee et al. [2] concluded:
It is surprising that despite our current level of understanding of the common mucosal immune system, almost all current vaccines are given to humans by the parenteral route [i.e. by injection]. Systemic immunization is essentially ineffective for induction of mucosal immune responses. Since the majority of infectious microorganisms are encountered through mucosal surface areas, it is logical to consider the induction of protective antibodies and T cell responses in mucosal tissues.
The failure of intramuscular injection to induce secretory IgA has been confirmed in a study on Middle East Respiratory Syndrome (MERS) [3]. Like COVID-19, this disease is caused by a coronavirus, and the experimental vaccine used in the study was gene-based, like all of the major vaccines currently deployed against COVID-19. More recently, another study has shown that the mRNA COVID-vaccines also do not stimulate substantive production of secretory IgA [4]. For this simple reason, one cannot expect that vaccination will inhibit airway infection. Indeed, the utter failure of the vaccines to prevent SARS-CoV-2 infection is today solidly documented [5,6].
It is general knowledge that secretory IgA antibodies (sIgA) are produced in response to naturally occurring airway infections. The mucous membranes of healthy individuals are consequently coated with antibodies directed against common respiratory viruses. However, the capacity of these antibodies to prevent infections is limited. The outcome of an encounter with a virus is not “black or white”—numbers are all-important. A wall of protective antibodies may ward off a small-scale attack, but it will be breached at higher viral loads. This is why infections with airborne viruses occur repeatedly throughout life, a fact that will not even be altered by the use of intranasal vaccines in order to stimulate sIgA-production, even though intranasal vaccine application does induce stronger mucosal immune responses than does intramuscular injection [3,7].
The subordinate role of secretory IgA in combating systemic viral infections is highlighted by the fact that individuals with a very common genetic defect—selective sIgA deficiency—who are unable to produce sIgA do not suffer from dramatically increased susceptibility toward severe respiratory infections. This observation can be understood from the following two principles: firstly, immunological protection against respiratory viruses rests mainly on T-cells; and secondly, in those with preexisting immunity, levels of bloodstream antibodies (circulating IgG and IgA) are generally sufficient to prevent severe disease through viral spread within the body.
44 mins agoAuthor
https://palexander.substack.com/p/respiratory-mucosal-layer-and-mucosal
I’ve said it numerous times. It’s an obvious & unequivocal mismatch in the broad field of “PK/PD”.
I am however subjected to extreme censorship, and I reason this is because I’m the most senior, former big pharma research executive anywhere who is speaking out about the ongoing attacks upon humanity.
This concept is a universal consideration involved in biopharmaceutical R&D.
This question always arises: “Is the amount of free drug in the anatomically required compartment sufficient & for long enough to even potentially bring about the desired alteration?”
Unless the answer is “Yes”, the molecule in question should not be advanced further into development.
It’s not different here. I confess it didn’t occur to me to realise that this consideration applies as much as in any other field of biomedical R&D.
There’s been no pandemic, no public health emergency. There was never any need for novel treatments because there was nothing new happening, except deliberately altered medical procedures in hospitals, care homes and the community. These altered medical procedures were the cause of the deaths declared as proof of “the pandemic”.
Obviously there was also no need of a new technology “vaccine”, which in my considerable experience, were designed to injure, kill and reduce fertility in survivors.
Even if there had been a novel health risk, we were told that only the frail elderly were at substantial elevated risk. So why inject healthy people with untested agents? Why mandate it? Why inject almost 6 billion people?
It’s a tough concept to grasp, I recognize.
Most refuse to accept that people they don’t know could possibly cook up such an arrangement. Yet they have.
I definitely didn’t start there. I watched mainstream TV & largely believed the news, too.
But such has been the obvious assaults upon the people that I was forced to take a fresh look at everything.
just nowAuthor
again, this is massive sharing by you and thank you, I am sharing far and wide...and ask all here to do same...I think people are so afraid to grasp that they fell for it and can be at risk longer term...but we must share here so that people can share ad educate others to help make more informed decisions. huge hugs and love to you Dr. Yeadon, you are a true leader in this global fight. in short, everything, all, 100% of COVID was a lie...including the response. the medical response in hospitals killed we estimate 95% of persons.
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key is if one argues that the circulatory IgG and IgA in the blood stream can mitigate the pathogen once it enters the bloodstream, one must understand that for that to occur, you would be very ill and likely will die of viremia, blood sepsis infection. for pathogen to breach the respiratory compartment into the blood, it is very very grave.
I’ve been telling you for quite a while now and even longer ago in other places what the exact primary mechanism of action is of all these viral mRNA products and how that inevitably leads to the conditions that are responsible for sudden death, a very wide variety of adverse event, and increasingly higher rates of all-cause, excess mortality around the world in a SINGLE POPULATION: those who have been injected with viral mRNA products.
And regarding those products, I have repeatedly told you there is no such thing as “mRNA technology.” That term was a marketing ploy devised to create the illusion there was some new, advanced vaccine technology. There is ONLY the seriously dangerous off-label use of cell transfection reagents that have been around and in common use for over 40 years in molecular biology labs around the world.
How do I know? Because I have used them in the lab innumerable times since the latter 1990s to introduce genes (whether mouse, human, or insect, or chimeras) into commonly used immortal cell lines to express exogenous proteins in order to study their behavior in the context of a living cell.
All this is, by this point in time, an utterly trivial process with absolutely no mystery at all. Everyone who uses it knows how it’s done and why it works. They also know what would be seriously complicating factors in its use (doing so in a multicellular, especially vertebrate organism), why that would be so (because vertebrate organisms, unlike cell culture, have innate and adaptive immune systems), and what would be a seriously dangerous use of these cell transfection reagents (using them to introduce viral genes indiscriminately into healthy cells simultaneously in multiple organ systems) and why (because cells have internal sensors that detect the presence of viral mRNA and viral proteins in the cytosol, because that is the minimum necessary condition to trigger signaling to the innate immune system that those cells are in viral replication mode, because the result of that are innate immune inflammatory attacks on those multiple locations and the organs containing those cells, because the more cells are involved, the greater the inflammatory response, because the greater the number of different organ systems are involved, the even greater that whole body innate immune inflammatory response).
NONE of this is hypothesized. This is all just basic molecular biology and immunology.
Here are the facts:
1. Do all the viral mRNA products to date rely on one or another of at least seven standards cell transfection reagents or methods?
YES.
2. Do all the viral mRNA products except for AstraZeneca indiscriminately get internalized into any cells they bump into?
YES.
3. Do all the viral mRNA products, including AstraZeneca, rely on getting viral mRNA introduced to the cells’ ribosomal protein synthesis equipment?
YES.
4. Do those cells automatically and without any means of control produce as much viral protein as there are copies of the viral mRNA coding for that gene?
YES.
5. Can very large amounts of a foreign protein produced in unregulated fashion also cause the compromised cells to sicken and die?
YES
6. Do the events in 5 also have their own immunological consequences in addition to the earlier signaling by those cells about the presence of viral mRNA and viral protein?
YES
7. Do multiple levels of innate immune attack act synergistically to produce even greater innate immune response and can that response cause impairment of organ function?
YES
8. Can those levels be great enough, especially in the context of preexisting comorbid conditions, to impair organ function to a point were serious disability or even death results?
YES.
9. Is it possible that simultaneous damage to multiple organ systems can also cause serious damage or death?
YES
10. Are ANY of 1-9 above anything that has not been known for years before ANY viral mRNA product was ever created because it’s all been extensively documented as the result of viral infection and immunological response to that infection?
NO
11. Of all the most serious consequences for the continued health of the vertebrate organism caused by viral infection anything fundamentally different (except for degree) than the effects of the viral mRNA products?
NO
12. Are multiple organ systems throughout the body compromised by viral mRNA products in a dose-dependent fashion?
YES.
13. Except for apoptotic events in these cells leading to their deaths, does the other signaling from these cells, inevitably driven by these viral mRNA products, lead to innate immune inflammatory attacks on those cells and the organs housing them?
YES
14. Can excessive inflammatory attacks on major organ systems lead to disability and death?
YES.
15. So when all cause mortality increases, is that due to dysfunction in one or another organ system?
YES.
16. Are the large increases in all cause mortality worldwide seen A. Uniformly throughout the entire population, B. In those who have received the viral mRNA products, C. In those who have NOT received the viral mRNA products?
Answer: they are seen in B
17. Of those individuals in B, do the numbers in adverse evens and the percentage of all cause mortality increase in a dose-dependent fashion with the number of viral mRNA products?
YES.
18. So what obviously accounts for the increase in all-cause mortality and organ system malfunction in those receiving the viral mRNA products regardless of age, gender, and state of comorbidity since the beginning of at least 2021?
Answer: That would be the serious innate immune inflammatory attacks in product-compromised cells and the organs that house them being compounded with increasing numbers of doses.
19. Is this primary mechanism of action and the inevitable immunological consequences arising from them sufficient to explain
A. Increases in all cause mortality,
B. Increases in contracting other viral and other opportunistic diseases, and
C. increases in rates, types, and severity of neoplastic disease in all age groups but almost entirely limits to people who have been injected one or more times with the viral mRNA products that are the functional equivalent of indiscriminate, one-gene, artificial viruses constructed from cell transfection reagents and PCR-produced viral spike protein genes?
ANSWERS
A. YES, because multiple organ systems are being whacked.
B. YES, because the innate immune system is swamped cleaning up the mess, reducing the number of other events the innate immune system can respond to and deal with,
C. YES, what the innate immune system does in B is also responsible for spotting and taking out neoplasms at their earliest stages. Impair that? Increase the numbers of cancers.
The cause of all these effects is something that takes place starting within the first couple hours after injection: and that is the invasion and infection of healthy cells in multiple organ systems with a viral gene.