Is there a link between COVID (SARS-COV-2) gene mRNA technology vaccination & new onset or worsening of inflammatory and autoimmune skin diseases? Yes! Hinterseher et al.'s meta-analysis shows us

Autoimmune skin disorders and SARS-CoV-2 vaccination – a meta-analysis; a link between COVID mRNA vaccination and new onset or worsening of inflammatory and autoimmune skin diseases (Pfizer etc.)

https://onlinelibrary.wiley.com/doi/10.1111/ddg.15114

‘Material and methods

A systematic meta-analysis of the literature on new onset or worsening of inflammatory and autoimmune diseases after SARS-CoV-2 vaccination was performed according to the PRISMA guidelines. The search strategy included following terms: “COVID-19/SARS-CoV-2 vaccine bullous pemphigoid/pemphigus vulgaris/systemic lupus erythematosus/dermatomyositis/lichen planus/leukocytoclastic vasculitis.” Moreover, we describe representative cases from our dermatology department.

Results

The database-search in MEDLINE identified 31 publications on bullous pemphigoid, 24 on pemphigus vulgaris, 65 on systemic lupus erythematosus, nine on dermatomyositis, 30 on lichen planus, and 37 on leukocytoclastic vasculitis until June 30th, 2022. Severity and response to treatment varied among the described cases.

Conclusions

Our meta-analysis highlights a link between SARS-CoV-2 vaccination and new onset or worsening of inflammatory and autoimmune skin diseases. Moreover, the extent of disease exacerbation has been exemplified by cases from our dermatological department.’

‘there is suggestive evidence that new onset or worsening of autoimmune skin disease is associated with SARS-CoV-2 vaccination. In fact, as described above, some patients from our clinic showed a significant worsening or new onset of autoimmune disease after SARS-CoV-2 vaccination.’

FIGURE 1

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New onset of bullous pemphigoid circa three weeks after mRNA-based SARS-CoV-2 vaccination. (a) Erythematous patches on both feet with a single tense blister on the link foot. (b) Erythematous patches with superficial erosions on the left hand. (c) Tense blisters on erythematous skin on the left calf.