Konstantin Föhse et al; key paper swept under the rug, I re-highlight "The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses"

Key statement for our purposes: "the mRNA 49 BNT162b2 vaccine induces complex functional reprogramming of innate immune responses, which should be considered in the development...of vaccines"

SOURCE:

The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses

I dealt with this before but felt I would again…the time has come to call for autopsies of all who die post COVID mRNA vaccine particularly to understand why. Especially those proximal to the shot e.g. in days to 2 weeks or so post shot or even up to one month. There are answers there and we need them.

These researchers out of the Netherlands (Föhse et al.) looked at Pfizer vaccine (BNT162b2 mRNA vaccine) and concluded that we are seeing alterations of innate immune response. Their research helped highlight again that antibodies (Abs) are very important but it is the T-cell (cellular) response that is critical. It is not only about Abs, the key part is the T-cell response. They looked post vaccine. This innate immune system is not on line post shot and seems to be dysregulated. Toll-like receptors 7 and 8 are key to signal e.g. signals key aspects to be turned on to fight viruses etc. This Netherland study showed that these toll-like receptors 7 and 8 are down regulated post injection and there is and will be a spike in viruses due to this, latent viruses, cancers etc. Additional gene receptors that the spike protein binds to e.g. P53 tumor suppressor gene, P53 is the GUARDIAN of our genome and dysregulating P53 can cause a spike in cancers we should not be seeing, in ages we should not see this etc. We are seeing this now.

So a key statement made by the researchers was: “the BNT162b2 vaccine also modulated the production of inflammatory cytokines by innate immune cells upon stimulation with both specific (SARS-CoV-2) and non-specific (viral, fungal and bacterial) stimuli. The response of innate immune cells to TLR4 and TLR7/8 ligands was lower after BNT162b2 vaccination, while fungi-induced cytokine responses were stronger.”

As part of the conclusion and some key passages I wanted to highlight:

“In conclusion, our data show that the BNT162b2 vaccine induces effects on both the adaptive and the innate branch of immunity and that these effects are different for various SARS-CoV-2 strains. Intriguingly, the BNT162b2 vaccine induces reprogramming of innate immune responses as well, and this needs to be taken into account: in combination with strong adaptive immune responses, this could contribute to a more balanced inflammatory reaction during COVID-19 infection, or it may contribute to a diminished innate immune response towards the virus.”

Abstract: “The mRNA-based BNT162b2 vaccine from Pfizer/BioNTech was the first registered COVID-19 vaccine and has been shown to be up to 95% effective in preventing SARS-CoV-2 infections. Little is known about the broad effects of the new class of mRNA vaccines, especially whether they have combined effects on innate and adaptive immune responses. Here we confirmed that BNT162b2 vaccination of healthy individuals induced effective humoral and cellular immunity against several SARS-CoV-2 variants. Interestingly, however, the BNT162b2 vaccine also modulated the production of inflammatory cytokines by innate immune cells upon stimulation with both specific (SARS-CoV-2) and non-specific (viral, fungal and bacterial) stimuli. The response of innate immune cells to TLR4 and TLR7/8 ligands was lower after BNT162b2 vaccination, while fungi-induced cytokine responses were stronger. In conclusion, the mRNA BNT162b2 vaccine induces complex functional reprogramming of innate immune responses, which should be considered in the development and use of this new class of vaccines.”

“The effect of the BNT162b2 vaccination on innate immune responses may also indicate a potential to interfere with the responses to other vaccinations, as known for other vaccines to be as ‘vaccine interference’ (Lum et al., 2010; Nolan et al., 2008; Vajo, Tamas, Sinka, & 211 Jankovics, 2010). Future studies are therefore needed to investigate this possibility, especially the potential interaction with the influenza vaccine: in the coming years (including the autumn of 2021) COVID-19 vaccination programs will probably overlap with the seasonal Influenza vaccination, so it is crucial to perform additional studies to elucidate the potential interactions and effects of the COVID-19 vaccines with the current vaccination schedules, especially for immunosuppressed and elderly individuals.”