SOURCE:
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.318902
‘administered a pseudo-virus expressing S protein (Pseu-Spike) to Syrian hamsters intratracheally. Lung damage was apparent in animals receiving Pseu-Spike, revealed by thickening of the alveolar septa and increased infiltration of mononuclear cells’.
‘In the damaged lungs, levels of pAMPK (phospho-AMPK), pACE2 (phospho-ACE2), and ACE2 decreased but those of MDM2 increased’.
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Dear Readers,
I also embed this short piece on The Wellness Company and The UNITY Project.
First, The Wellness Company.
I am proud to announce a unique partnership with The Wellness Company and everyone who believes in medical freedom. My dear and esteemed colleagues Dr. Peter McCullough and Dr. Harvey Risch are also in partnership with The Wellness Company which provides telemedicine services for long-haul COVID, vaccine injury, and medical exemptions along with supplements and products that are fully aligned with our values. This support for The Wellness Company stems from the sub-optimal medical care and response that we experienced throughout the pandemic. It became apparent that there are many glaring gaps in our healthcare system and people were not properly treated. Thus, the pivot by us to support The Wellness Company. Take a stand against a broken healthcare delivery system with a membership in The Wellness Company, which directly funds our fight against medical tyranny. Click here The Wellness Company for more information.Â
I also provide scientific support to The UNITY Project out of California. A magical organization for good. I support this tremendous initiative with some fine colleagues who have been warriors in the fight against all the wrongs in COVID. The UNITY Project aligns with my core values for it is very fierce in its fight to protect children from the danger of the largely safety untested COVID gene injection (The Unity Project Formed by Concerned Parents to Coordinate Opposition to California's K-12 COVID-19 Vaccination Mandate) (contact: info@theunityproject.org).
I just became a paid subscriber and I also have your book and listening to it on my Audible app. it’s an amazing read. I can’t understand why Fauci hasn’t already been indicted. There is an unbelievable amount of corruption in our government agencies. So glad there are others like yourself willing to expose this corruption.
It appears that there is long-term rewiring of innate immunity. There's learned down regulation of Neutrophils and Monocytes leading to enhanced secondary infections, leading to huge sepsis from these.
Properly functioning innate immunity is the only barrier standing in the way of severe disease from infection and secondary infection. If this is being repeatedly downregulated from repeated exposure to SARS-CoV-2's highly immunogenic spike protein, then we are in big trouble. And, with secondary infections in particular, if there's too much upregulation then the organs will be inflamed to the point of failure.
COVID is training the innate immune system to trigger blood clots instead of attacking COVID and other types of infections, before they infect the cells in the organs. Hard wired immune tolerance for phagocytes from repeat SARS-CoV-2 exposure. Once they develop a paralysis response we open Pandora’s box of opportunistic infections.
Thus it appears that we have another disease that destroys the immune system on our hands that is like HIV only much worse.
Abstract
"Although alterations in myeloid cells have been observed in COVID-19, the specific underlying mechanisms are not completely understood. Here, we examine the function of classical CD14+Â monocytes in patients with mild and moderate COVID-19 during the acute phase of infection and in healthy individuals. Monocytes from COVID-19 patients display altered expression of cell surface receptors and a dysfunctional metabolic profile that distinguish them from healthy monocytes. Secondary pathogen sensing ex vivo leads to defects in pro-inflammatory cytokine and type-I IFN production in moderate COVID-19 cases, together with defects in glycolysis. COVID-19 monocytes switch their gene expression profile from canonical innate immune to pro-thrombotic signatures and are functionally pro-thrombotic, both at baseline and following ex vivo stimulation with SARS-CoV-2. Transcriptionally, COVID-19 monocytes are characterized by enrichment of pathways involved in hemostasis, immunothrombosis, platelet aggregation and other accessory pathways to platelet activation and clot formation. These results identify a potential mechanism by which monocyte dysfunction may contribute to COVID-19 pathology."
Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19
https://www.nature.com/articles/s41467-022-35638-y