Lei et al.: "SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2"; show that Spike protein 'alone' can damage vascular endothelial cells (ECs) by downregulating ACE2
Lei et al.: "SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2"; show that Spike protein 'alone' can damage vascular endothelial cells (ECs) by downregulating ACE2
COVID-19 is & was a vascular (blood clot) disease (as much as respiratory) & the SARS-CoV-2 virus (spike protein) attacks vascular system on a cellular level (spike protein from vaccine OR infection)
I just became a paid subscriber and I also have your book and listening to it on my Audible app. it’s an amazing read. I can’t understand why Fauci hasn’t already been indicted. There is an unbelievable amount of corruption in our government agencies. So glad there are others like yourself willing to expose this corruption.
It appears that there is long-term rewiring of innate immunity. There's learned down regulation of Neutrophils and Monocytes leading to enhanced secondary infections, leading to huge sepsis from these.
Properly functioning innate immunity is the only barrier standing in the way of severe disease from infection and secondary infection. If this is being repeatedly downregulated from repeated exposure to SARS-CoV-2's highly immunogenic spike protein, then we are in big trouble. And, with secondary infections in particular, if there's too much upregulation then the organs will be inflamed to the point of failure.
COVID is training the innate immune system to trigger blood clots instead of attacking COVID and other types of infections, before they infect the cells in the organs. Hard wired immune tolerance for phagocytes from repeat SARS-CoV-2 exposure. Once they develop a paralysis response we open Pandora’s box of opportunistic infections.
Thus it appears that we have another disease that destroys the immune system on our hands that is like HIV only much worse.
Abstract
"Although alterations in myeloid cells have been observed in COVID-19, the specific underlying mechanisms are not completely understood. Here, we examine the function of classical CD14+ monocytes in patients with mild and moderate COVID-19 during the acute phase of infection and in healthy individuals. Monocytes from COVID-19 patients display altered expression of cell surface receptors and a dysfunctional metabolic profile that distinguish them from healthy monocytes. Secondary pathogen sensing ex vivo leads to defects in pro-inflammatory cytokine and type-I IFN production in moderate COVID-19 cases, together with defects in glycolysis. COVID-19 monocytes switch their gene expression profile from canonical innate immune to pro-thrombotic signatures and are functionally pro-thrombotic, both at baseline and following ex vivo stimulation with SARS-CoV-2. Transcriptionally, COVID-19 monocytes are characterized by enrichment of pathways involved in hemostasis, immunothrombosis, platelet aggregation and other accessory pathways to platelet activation and clot formation. These results identify a potential mechanism by which monocyte dysfunction may contribute to COVID-19 pathology."
Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19
What other virus has the ability to cause blood clots? If SARS CoV-2 has this symptom then it seems likely 10's of millions would have died and it could be proven by autopsies. Again, the medical community has no clue. Why wasn't this seen or known 30 months ago?
Why did they use the business end of the disease, the spike, as the business end of the vaccine? Couldn’t they have picked some other less lethal aspect to get our cells to produce and create antibodies for?
Happy New Year Dr Paul Alexander and thank you for your courageous work!
Interesting article!
In layman's terms: "THE COVID-19 VAXXED ARE SCREWED!"
I’m not trying to be funny here – it’s anything but funny.
Get a treatment protocol that includes Ivermectin and start taking it, STAT, for as long as it takes to clear all the vaxx poisons out of your system and start to rebuild your natural immunity.
Thank you for presenting real science/research....which increasing builds the foundation for conveying the unshakable truth to those who’ll embrace it.
When confronted about this study the pro-jab ears say that the amount of spike protein expressed or received was in far greater concentrations than people get from the vax and that at lower concentrations it is not an endothelial toxin.
Please express your views regarding germ theory. The truth about viruses needs to be explored, I am inclined to believe the position of Dr Tom Cowan. Dr. Andrew Kauffman Dr's Sam and Mark Bailey and Steve Falconer- and if this is the real truth the ramifications are huge. It will certainly be in the best interest of humanity to expose this. It really means all vaccines are designed to hurt us, and make the medical community prosper at our expense. The scientific method must be followed and we can't be Taking shots based on unproven hypotheses
I just became a paid subscriber and I also have your book and listening to it on my Audible app. it’s an amazing read. I can’t understand why Fauci hasn’t already been indicted. There is an unbelievable amount of corruption in our government agencies. So glad there are others like yourself willing to expose this corruption.
It appears that there is long-term rewiring of innate immunity. There's learned down regulation of Neutrophils and Monocytes leading to enhanced secondary infections, leading to huge sepsis from these.
Properly functioning innate immunity is the only barrier standing in the way of severe disease from infection and secondary infection. If this is being repeatedly downregulated from repeated exposure to SARS-CoV-2's highly immunogenic spike protein, then we are in big trouble. And, with secondary infections in particular, if there's too much upregulation then the organs will be inflamed to the point of failure.
COVID is training the innate immune system to trigger blood clots instead of attacking COVID and other types of infections, before they infect the cells in the organs. Hard wired immune tolerance for phagocytes from repeat SARS-CoV-2 exposure. Once they develop a paralysis response we open Pandora’s box of opportunistic infections.
Thus it appears that we have another disease that destroys the immune system on our hands that is like HIV only much worse.
Abstract
"Although alterations in myeloid cells have been observed in COVID-19, the specific underlying mechanisms are not completely understood. Here, we examine the function of classical CD14+ monocytes in patients with mild and moderate COVID-19 during the acute phase of infection and in healthy individuals. Monocytes from COVID-19 patients display altered expression of cell surface receptors and a dysfunctional metabolic profile that distinguish them from healthy monocytes. Secondary pathogen sensing ex vivo leads to defects in pro-inflammatory cytokine and type-I IFN production in moderate COVID-19 cases, together with defects in glycolysis. COVID-19 monocytes switch their gene expression profile from canonical innate immune to pro-thrombotic signatures and are functionally pro-thrombotic, both at baseline and following ex vivo stimulation with SARS-CoV-2. Transcriptionally, COVID-19 monocytes are characterized by enrichment of pathways involved in hemostasis, immunothrombosis, platelet aggregation and other accessory pathways to platelet activation and clot formation. These results identify a potential mechanism by which monocyte dysfunction may contribute to COVID-19 pathology."
Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19
https://www.nature.com/articles/s41467-022-35638-y
What other virus has the ability to cause blood clots? If SARS CoV-2 has this symptom then it seems likely 10's of millions would have died and it could be proven by autopsies. Again, the medical community has no clue. Why wasn't this seen or known 30 months ago?
Why did they use the business end of the disease, the spike, as the business end of the vaccine? Couldn’t they have picked some other less lethal aspect to get our cells to produce and create antibodies for?
Happy New Year Dr Paul Alexander and thank you for your courageous work!
Interesting article!
In layman's terms: "THE COVID-19 VAXXED ARE SCREWED!"
I’m not trying to be funny here – it’s anything but funny.
Get a treatment protocol that includes Ivermectin and start taking it, STAT, for as long as it takes to clear all the vaxx poisons out of your system and start to rebuild your natural immunity.
Thank you for presenting real science/research....which increasing builds the foundation for conveying the unshakable truth to those who’ll embrace it.
When confronted about this study the pro-jab ears say that the amount of spike protein expressed or received was in far greater concentrations than people get from the vax and that at lower concentrations it is not an endothelial toxin.
Please express your views regarding germ theory. The truth about viruses needs to be explored, I am inclined to believe the position of Dr Tom Cowan. Dr. Andrew Kauffman Dr's Sam and Mark Bailey and Steve Falconer- and if this is the real truth the ramifications are huge. It will certainly be in the best interest of humanity to expose this. It really means all vaccines are designed to hurt us, and make the medical community prosper at our expense. The scientific method must be followed and we can't be Taking shots based on unproven hypotheses