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SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis; case of a 52-year-old male, presenting with bimodal episodes of acute hepatitis, each occurring 2-3 weeks after BNT162b2 mRNA vax

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SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis; case of a 52-year-old male, presenting with bimodal episodes of acute hepatitis, each occurring 2-3 weeks after BNT162b2 mRNA vax

Liver inflammation is observed during SARS-CoV-2 infection but can also occur in some individuals after vaccination and shares some typical features with autoimmune liver disease.

Dr. Paul Alexander
Apr 26, 2022
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SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis; case of a 52-year-old male, presenting with bimodal episodes of acute hepatitis, each occurring 2-3 weeks after BNT162b2 mRNA vax

palexander.substack.com

Source:

SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis

This paper on vax induced autoimmune hepatitis is very interesting and troubling and wroth sharing. A 52-year-old male, presenting with bimodal episodes of acute hepatitis, each occurring 2-3 weeks after BNT162b2 mRNA vaccination.

The key findings in the report are:

“Analysis of the hepatic tissue revealed an immune infiltrate quantitatively dominated by activated cytotoxic CD8 T cells with panlobular distribution. An enrichment of CD4 T cells, B cells, plasma cells and myeloid cells was also observed compared to controls. The intrahepatic infiltrate showed enrichment for CD8 T cells with SARS-CoV-2-specificity compared to the peripheral blood. Notably, hepatitis severity correlated longitudinally with an activated cytotoxic phenotype of peripheral SARS-CoV-2-specific, but not EBV-specific CD8+ T cells or vaccine-induced immunoglobulins.

Conclusions

COVID19 vaccination can elicit a distinct T cell-dominant immune-mediated hepatitis with a unique pathomechanism associated with vaccination induced antigen-specific tissue-resident immunity requiring systemic immunosuppression.

Lay summary

Liver inflammation is observed during SARS-CoV-2 infection but can also occur in some individuals after vaccination and shares some typical features with autoimmune liver disease. In this report, we show that highly activated T cells accumulate and are evenly distributed in the different areas of the liver in a patient with liver inflammation following SARS-CoV-2 vaccination.”

See additional study:

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SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis; case of a 52-year-old male, presenting with bimodal episodes of acute hepatitis, each occurring 2-3 weeks after BNT162b2 mRNA vax

palexander.substack.com
14 Comments
Sheri Yuckert
Apr 26, 2022

Is ANYONE looking into how the vaccines are affecting our blood supply? Is it safe to get. Blood transfusion from someone who has been vaccinated? I haven’t seen anything on this subject.

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Sunshinegirl1217
Apr 26, 2022

If kids getting hepatitis aren't vaccinated is it possible they contract it being around vaccinated adults shedding it?

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