Shimizu et al.: "Reevaluation of antibody-dependent enhancement of infection in anti-SARS-CoV-2 therapeutic antibodies and mRNA-vaccine antisera using FcR- and ACE2-positive cells
Shimizu et al.: "Reevaluation of antibody-dependent enhancement of infection in anti-SARS-CoV-2 therapeutic antibodies and mRNA-vaccine antisera using FcR- and ACE2-positive cells
we demonstrate (in-vitro) that certain monoclonal Abs (mAbs) approved as therapeutic neutralizing anti-S-protein mAbs for human usage have potential to cause ADE in a narrow range of Ab concentration.
From that study: "These results suggest that the rapid spread of Omicron around the world may in part result from the lack of cross-neutralization against Omicron and some ADE activity of sera after vaccination."
Looks like the anti-vaxxing conspiracy theorists were right again: The vaxxiines are not only causing ADE, they also keep the plandemic going by pressure-selecting vaxxiine-resistant variants.
Hmm, yeah, a lot of nuance to this study. Interesting that the sotrovimab did not cause the ADE potential. In vitro has generally held up well to the in vivo in SARS2.
So therapeutic monoclonal antibodies can cause ADE!!! This is something that for sure needs to be talked about. Do these antibodies stay around for how long? Is the enhancement temporary?
If this weren’t real life, I’d have a hard time believing this.
So 2 monoclonals cause ADE along with Moderna jabs in vitro. Hmm
From that study: "These results suggest that the rapid spread of Omicron around the world may in part result from the lack of cross-neutralization against Omicron and some ADE activity of sera after vaccination."
Looks like the anti-vaxxing conspiracy theorists were right again: The vaxxiines are not only causing ADE, they also keep the plandemic going by pressure-selecting vaxxiine-resistant variants.
I want to check on which monoclonal abs I received, yikes.
Hmm, yeah, a lot of nuance to this study. Interesting that the sotrovimab did not cause the ADE potential. In vitro has generally held up well to the in vivo in SARS2.
Dr. Alexander, Is it known if the ADE mechanism from the monoclonal ABs is similar or the same as that shown by Fantini et. al.?
So therapeutic monoclonal antibodies can cause ADE!!! This is something that for sure needs to be talked about. Do these antibodies stay around for how long? Is the enhancement temporary?
So are you saying monoclonal by itself - no vax - also causes ADE?