Shimizu et al.: "Reevaluation of antibody-dependent enhancement of infection in anti-SARS-CoV-2 therapeutic antibodies and mRNA-vaccine antisera using FcR- and ACE2-positive cells
Shimizu et al.: "Reevaluation of antibody-dependent enhancement of infection in anti-SARS-CoV-2 therapeutic antibodies and mRNA-vaccine antisera using FcR- and ACE2-positive cells
we demonstrate (in-vitro) that certain monoclonal Abs (mAbs) approved as therapeutic neutralizing anti-S-protein mAbs for human usage have potential to cause ADE in a narrow range of Ab concentration.
When I read a bit about the monoclonal antibodies and how they were produced, my gut reaction was a hard pass for me. I hope all the people who had these don’t end up more at risk.
Remember that those monoclonals were sourced from people previously infected with SARS-COV2 i.e. naturally immune. Rather than look at this from a position of cynicism, look at it from the scientific perspective and understand the relationship between monoclonal antibodies as therapies, the antibodies produced by the vaccines, and the antibodies that we produce via natural infection. They are a lot more related than we make them out to be and it's far more important that we look at them with a nuanced perspective.
From that study: "These results suggest that the rapid spread of Omicron around the world may in part result from the lack of cross-neutralization against Omicron and some ADE activity of sera after vaccination."
Looks like the anti-vaxxing conspiracy theorists were right again: The vaxxiines are not only causing ADE, they also keep the plandemic going by pressure-selecting vaxxiine-resistant variants.
Hmm, yeah, a lot of nuance to this study. Interesting that the sotrovimab did not cause the ADE potential. In vitro has generally held up well to the in vivo in SARS2.
So therapeutic monoclonal antibodies can cause ADE!!! This is something that for sure needs to be talked about. Do these antibodies stay around for how long? Is the enhancement temporary?
If you're not generating those antibodies, no. It just means they would potentially make an infection worse if given when a virus can use them to further the infection. I think there might be other potential problems with monoclonals, e.g. they could inhibit the body's ability to develop immune memory if given unnecessarily during an infection. But that's not like getting a transfection/"vaccine".
Thx. My husband and I got monoclonal when we had delta. We were negative in 5 days so it works but I do worry about any potential side effects from mab.
If this weren’t real life, I’d have a hard time believing this.
So 2 monoclonals cause ADE along with Moderna jabs in vitro. Hmm
When I read a bit about the monoclonal antibodies and how they were produced, my gut reaction was a hard pass for me. I hope all the people who had these don’t end up more at risk.
Remember that those monoclonals were sourced from people previously infected with SARS-COV2 i.e. naturally immune. Rather than look at this from a position of cynicism, look at it from the scientific perspective and understand the relationship between monoclonal antibodies as therapies, the antibodies produced by the vaccines, and the antibodies that we produce via natural infection. They are a lot more related than we make them out to be and it's far more important that we look at them with a nuanced perspective.
From that study: "These results suggest that the rapid spread of Omicron around the world may in part result from the lack of cross-neutralization against Omicron and some ADE activity of sera after vaccination."
Looks like the anti-vaxxing conspiracy theorists were right again: The vaxxiines are not only causing ADE, they also keep the plandemic going by pressure-selecting vaxxiine-resistant variants.
I want to check on which monoclonal abs I received, yikes.
Hmm, yeah, a lot of nuance to this study. Interesting that the sotrovimab did not cause the ADE potential. In vitro has generally held up well to the in vivo in SARS2.
Dr. Alexander, Is it known if the ADE mechanism from the monoclonal ABs is similar or the same as that shown by Fantini et. al.?
So therapeutic monoclonal antibodies can cause ADE!!! This is something that for sure needs to be talked about. Do these antibodies stay around for how long? Is the enhancement temporary?
So are you saying monoclonal by itself - no vax - also causes ADE?
If you're not generating those antibodies, no. It just means they would potentially make an infection worse if given when a virus can use them to further the infection. I think there might be other potential problems with monoclonals, e.g. they could inhibit the body's ability to develop immune memory if given unnecessarily during an infection. But that's not like getting a transfection/"vaccine".
Thx. My husband and I got monoclonal when we had delta. We were negative in 5 days so it works but I do worry about any potential side effects from mab.