The reckless inventors of mRNA technology Karikó & Weissman et al. told us about the hell they were unleashing here: 'Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector
with Increased Translational Capacity and Biological Stability'; found that mRNAs containing pseudouridines have a higher translational capacity than unmodified mRNAs
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)32681-8
These ‘inventors’ knew what they invented and unleashed onto the world, it was never good, it was never safety tested, it was always dangerous and with the lipid-nano particile complex, was primed to deliver death to humanity.
It has.
‘The delivered mRNA and the encoded protein could be detected in the spleen at 1, 4, and 24 hours after the injection, where both products were at significantly higher levels when pseudouridine-containing mRNA was administered. Even at higher doses, only the unmodified mRNA was immunogenic, inducing high serum levels of interferon-α (IFN-α).’
‘These findings indicate that nucleoside modification is an effective approach to enhance stability and translational capacity of mRNA while diminishing its immunogenicity in vivo. Improved properties conferred by pseudouridine make such mRNA a promising tool for both gene replacement and vaccination.’
Those guys did not invent squat. They just used 40 year old cell transfection reagents in an off-label manner to infect cells in vivo with a viral gene.
And all this talk about “mRNA technology” is like calling a knife through the ribs “induced pulmonary ventilation.”
One group comes up with the phrase “mRNA technology” to make it sound and new and high-tech, ie, something other than what it is.
Another group comes up with the phrase “mRNA gene therapy” to make it sound high-tech and scary, ie, something other than what it is that would take too long for them to explain, if they were capable of that.
In vivo cell transfection with viral genes is not doing anything at the cellular level that hundreds of thousands of molecular/cell biologists haven’t been doing in vitro for a generation in basic research. But even they weren’t stupid enough to transfect cells in a live human being with viral genes.
Why?
Because even they knew the immunological consequences would be catastrophic.
How?
Imagine the virus that causes a wart. Now imagine the genes for that virus being introduced directly into cells throughout the body in multiple organ systems. Probable outcome based on just basic knowledge? Probably really good or probably really bad?
In vivo cell transfection to introduce viral genes is not doing anything at the cellular level that viruses haven’t been doing since before the human race ever existed. Viruses do it without thinking.
But Pfizer (and their later colluding copycats to snag the remaining easily-commercialized cell transfection reagents) did it intentionally.
Pfizer knew that the built-in sensors in the product compromised cells that detect the presence of viral mRNA and viral protein would trigger the innate immune system to launch innate immune inflammatory attacks to kill all those cells. And that is how the viral spike protein would be cleaned up by the innate immune system and carried by antigen presenter cells to the adaptive immune system to design specific antibodies and T cells.
And then those assholes said, “See that makes our product a vaccine.”
Gee, when you get bit by a rabid dog, your innate immune and adaptive immune systems go right to work and antibodies and T cells are produced.
Does that make the rabies virus into a vaccine.
You’ll have honest to goodness specific antibodies and killer T cells designed to attack the rabies virus. But if you don’t get immediate help and large doses of externally supplied antibodies you are still going to die because what you make on your own won’t be enough to save you. And once you start showing signs of a clinical infection, not even that will work.
Think of it, Pfizer claims that C19 viruses dumping their viral genes and making viral proteins in your ACE2-expressing cells in your respiratory tract, provoking innate immune inflammatory attacks, will kill you.
And then they use indiscriminate cell transfection reagents to dump C19 viral genes into cells throughout your body to make viral proteins, causing those cells to provoke innate immune inflammatory attacks in exactly the same way and for exactly the same reason as the native virus, just all over the place, and then Pfizer claims it’s a vaccine that will save you from a virus later on doing to you what they’re doing to you.
All this was known from the very beginning. It’s just basic biology, virology, and immunology 101 stuff.
But they did it anyway.
And almost all the critics talk about everything BUT the primary mechanism of action.
Hmm, pretty much the same approach as the crooks of Covid Inc.
You have GOT to wonder why.
Paul, Gregorio, All,
Probably a dumb question since Dr. Robert Malone claims he has 7 Patents on the "mRNA technology " but is he included in the perpetrators here?
Looking for conformation and other opinions.