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URGENT: Postvaccination immune exhaustion and fatigue from Pfizer mRNA vaccination: " Syenina, Adverse effects following anti–COVID-19 vaccination with mRNA-based Pfizer are alleviated by altering

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URGENT: Postvaccination immune exhaustion and fatigue from Pfizer mRNA vaccination: " Syenina, Adverse effects following anti–COVID-19 vaccination with mRNA-based Pfizer are alleviated by altering

the route of administration and correlate with baseline enrichment of T and NK cell genes (Syenina et al.)

Dr. Paul Alexander
Nov 12, 2022
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URGENT: Postvaccination immune exhaustion and fatigue from Pfizer mRNA vaccination: " Syenina, Adverse effects following anti–COVID-19 vaccination with mRNA-based Pfizer are alleviated by altering

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Ensuring high vaccination and even booster vaccination coverage is critical in preventing severe Coronavirus Disease 2019 (COVID-19). Among the various COVID-19 vaccines currently in use, the mRNA vaccines have shown remarkable effectiveness.

However, systemic adverse events (AEs), such as postvaccination fatigue, are prevalent following mRNA vaccination, and the underpinnings of which are not understood. Herein, we found that higher baseline expression of genes related to T and NK cell exhaustion and suppression were positively correlated with the development of moderately severe fatigue after Pfizer-BioNTech BNT162b2 vaccination; increased expression of genes associated with T and NK cell exhaustion and suppression reacted to vaccination were associated with greater levels of innate immune activation at 1 day postvaccination.

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We further found, in a mouse model, that altering the route of vaccination from intramuscular (i.m.) to subcutaneous (s.c.) could lessen the pro-inflammatory response and correspondingly the extent of systemic AEs; the humoral immune response to BNT162b2 vaccination was not compromised. Instead, it is possible that the s.c. route could improve cytotoxic CD8 T-cell responses to BNT162b2 vaccination. Our findings thus provide a glimpse of the molecular basis of postvaccination fatigue from mRNA vaccination and suggest a readily translatable solution to minimize systemic AEs.’

SOURCE:

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001643

Alexander COVID News-Dr. Paul Elias Alexander's Newsletter is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

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URGENT: Postvaccination immune exhaustion and fatigue from Pfizer mRNA vaccination: " Syenina, Adverse effects following anti–COVID-19 vaccination with mRNA-based Pfizer are alleviated by altering

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URGENT: Postvaccination immune exhaustion and fatigue from Pfizer mRNA vaccination: " Syenina, Adverse effects following anti–COVID-19 vaccination with mRNA-based Pfizer are alleviated by altering

palexander.substack.com
Joanne
Nov 12, 2022

How effective is a vax that one needs multiple jabs just to get less than what a non jabbed persons immune response is!?? Oh and risk does not outweigh benifit when one considers myocarditis or increase cancers or strokes from said vax.. ya. I’ll pass again.. stay healthy. Stay unjabbed!!

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stealthmouse
Writes The House of Pain
Nov 12, 2022

Why even bother with the opening paragraph? They know they're not "remarkably effective."

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