Alexander: Vitamin D & COVID-19: how important was vitamin D to COVID sequelae? Well, turns out very very important whereby 25-hydroxyvitamin D (25(OH)D)has inverse relationship with patient outcomes
2 studies are presented to demonstrate & vitamin D is not only needed to reduce COVID risk but also for a host of illnesses and it is critical for immune function; natural sunlight and supplements
Angelidi et al. conducted a retrospective, observational, cohort study at 2 tertiary academic medical centers in Boston and New York; found that “among patients admitted with laboratory-confirmed COVID-19, 25(OH)D levels were inversely associated with in-hospital mortality and the need for invasive mechanical ventilation.” “The final analysis included 144 patients with confirmed COVID-19 (median age, 66 years; 64 [44.4%] male). Overall mortality was 18%, whereas patients with 25(OH)D levels of 30 ng/mL (to convert to nmol/L, multiply by 2.496) and higher had lower rates of mortality compared with those with 25(OH)D levels below 30 ng/mL (9.2% vs 25.3%; p<0.02).”
2) SOURCE: SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels
Kaufman et al. conducted a retrospective, observational analysis of “deidentified tests performed at a national clinical laboratory to determine if circulating 25-hydroxyvitamin D (25(OH)D) levels are associated with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) positivity rates.”
Researchers looked at 191,779 patients with a median age, 54 years [interquartile range 40.4-64.7]; 68% female. They reported that “the SARS-CoV-2 positivity rate was 9.3% (95% C.I. 9.2-9.5%) and the mean seasonally adjusted 25(OH)D was 31.7 (SD 11.7). The SARS-CoV-2 positivity rate was higher in the 39,190 patients with "deficient" 25(OH)D values (<20 ng/mL) (12.5%, 95% C.I. 12.2-12.8%) than in the 27,870 patients with "adequate" values (30-34 ng/mL) (8.1%, 95% C.I. 7.8-8.4%) and the 12,321 patients with values ≥55 ng/mL (5.9%, 95% C.I. 5.5-6.4%).
The association between 25(OH)D levels and SARS-CoV-2 positivity was best fitted by the weighted second-order polynomial regression, which indicated strong correlation in the total population (R2 = 0.96) and in analyses stratified by all studied demographic factors. The association between lower SARS-CoV-2 positivity rates and higher circulating 25(OH)D levels remained significant in a multivariable logistic model adjusting for all included demographic factors (adjusted odds ratio 0.984 per ng/mL increment, 95% C.I. 0.983-0.986; p<0.001). SARS-CoV-2 positivity is strongly and inversely associated with circulating 25(OH)D levels, a relationship that persists across latitudes, races/ethnicities, both sexes, and age ranges.”
Thanks for the article Dr. Paul. I'm a self-employed contractor. I practiced masking and social distancing through the 1st wave to protect my customers and elderly parents.
I am unvaccinated, 47 years old. After researching the FLCC protocols, I have been taking Daily Vitamin D3 5000 IU since early 2021 with only symptoms being runny nose and sore throat for 24 hours. With first symptoms, I supplemented with one dose each of Quercetin 250mg and Zinc 30mg and Melatonin 3mg before bed. I suggested Vitamin D3, Vitamin C/Zinc and Multi for my Dad (75 years old, unvaccinated, never had a flu shot).
My Mom is Triple vaccinated (Moderna) and has been taking Vitamin D3 5000 IU for early Osteoporosis. No sign of severe illness in my close family members with Vitamin D3 3000-5000IU Daily regardless of vaccination. Thanks for reading!
...oh, facts!!!! How some of us still love you...and Vit D.!!!! :)