We have been warning of this that the more you vaccinate (and rapidly) the more you will drive the emergence of vaccine-resistant mutations and now we have emerging evidence

This is a huge problem and it underscores that if we use a non-sterilizing vaccine (sub-optimal) to implement population wide vaccine programs (mass vaccination) when pathogen is widely circulating, and you do this rapidly and aggressively, then the sub-optimal mounting immune pressure from vaccine antibodies intersecting with the infectious pressure from circulating virus, can drive the selection of highly infectious escape mutants. There is a risk that a variant may emerge that is lethal, rare but there is a potential.

“By tracking the evolutionary trajectories of vaccine-resistant mutations in more than 2.2 million SARS-CoV-2 genomes, we reveal that the occurrence and frequency of vaccine-resistant mutations correlate strongly with the vaccination rates in Europe and America. We anticipate that as a complementary transmission pathway, vaccine-breakthrough or antibody-resistant mutations, like those in Omicron, will become a dominating mechanism of SARS-CoV-2 evolution when most of the world’s population is either vaccinated or infected.”

100% these present COVID vaccines will never achieve population-level herd immunity. They are non-sterilizing and do not stop infection or transmission and thus cannot cut the chain of transmission. It is sheer lunacy now to go for a 3rd booster and even to think about a 4th. Pfizer CEO Bourla is a lunatic. It is clear now this is about power and profits, this is not about effective or safe vaccines.

url:

https://pubs.acs.org/doi/10.1021/acs.jpclett.1c03380