I have lived 25 years in Padang, Sumatra, and now two in Yogya, Java. In Padang I saw several cases of dengue, several of HDF, in the different age groups, among children and adults. I never saw my wife, a Minangkabau, suffer from it because she was probably already immune; my youngest daughter had sub-HDF, atypical, with no visible blee…
I have lived 25 years in Padang, Sumatra, and now two in Yogya, Java. In Padang I saw several cases of dengue, several of HDF, in the different age groups, among children and adults. I never saw my wife, a Minangkabau, suffer from it because she was probably already immune; my youngest daughter had sub-HDF, atypical, with no visible bleeding, but a leakage was measurable, when she was 10 or 12 years old, in fact for a week we had hospital laboratory blood checkups until the values had returned to normal, I had preferred not to hospitalize her. For a woman in her twenties who was an acquaintance of my wife, I had donated blood for transfusion being of the same group and rhesus because she suffered from DHF just when she was about to give birth with the doctors not wanting to intervene with medical therapies preferring transfusion; a few days the woman gave birth to a baby girl in good condition.
I didn't answer your question, "You raised a key issue for that vaccine was stopped, no? I think plasma leakage syndrome??" I am not a doctor, I can't. I imagine, a vaccine should act on the four serotypes in sync, is it feasible? Another possibility, I am guessing as a layman, would be to immunize according to a line of favorable serotypes, number m, n, o, p, one separated from the other at intervals of months, feasible for those who have never been exposed to the virus and go on vacation to certain risk regions. Typically, the situations are always much more complicated than imagined. Another case infinitely and devilishly more complex than one thinks is the one with the malaria plasmodium.
I have lived 25 years in Padang, Sumatra, and now two in Yogya, Java. In Padang I saw several cases of dengue, several of HDF, in the different age groups, among children and adults. I never saw my wife, a Minangkabau, suffer from it because she was probably already immune; my youngest daughter had sub-HDF, atypical, with no visible bleeding, but a leakage was measurable, when she was 10 or 12 years old, in fact for a week we had hospital laboratory blood checkups until the values had returned to normal, I had preferred not to hospitalize her. For a woman in her twenties who was an acquaintance of my wife, I had donated blood for transfusion being of the same group and rhesus because she suffered from DHF just when she was about to give birth with the doctors not wanting to intervene with medical therapies preferring transfusion; a few days the woman gave birth to a baby girl in good condition.
I didn't answer your question, "You raised a key issue for that vaccine was stopped, no? I think plasma leakage syndrome??" I am not a doctor, I can't. I imagine, a vaccine should act on the four serotypes in sync, is it feasible? Another possibility, I am guessing as a layman, would be to immunize according to a line of favorable serotypes, number m, n, o, p, one separated from the other at intervals of months, feasible for those who have never been exposed to the virus and go on vacation to certain risk regions. Typically, the situations are always much more complicated than imagined. Another case infinitely and devilishly more complex than one thinks is the one with the malaria plasmodium.
*a few days later, the woman...