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I presume single pilot flight decks are 100 or 1000 times as dangerous as dual pilot flight decks.

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Why would that be?

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Pre mRNA vaccine, let’s say that a pilot could become incapacitated every million flight hours. Under the stressful conditions of a pilot being incapacitated, perhaps a copilot would become incapacitated every 100,000 hours. Post mRNA, perhaps those numbers go to 100,000 and 100 or 1000.

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How was incapacitation defined and how was it caused in the cited statistics?

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Good question. It's unclear if a consistent and precise definition is being used in the cited statistics.

Nevertheless, I found this discussion, which looks good: https://skybrary.aero/articles/pilot-incapacitation

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