Senolytics show promise in combating brain aging and COVID-19 neuropathology
" ... human brain organoids (BOs) ... were treated with two doses of senolytics, such as the dasatinib-quercetin (D+Q) combination, ABT-737, and navitoclax, for one month at a two-week interval ... The researchers examined the associations of transcriptomic chang…
Senolytics show promise in combating brain aging and COVID-19 neuropathology
" ... human brain organoids (BOs) ... were treated with two doses of senolytics, such as the dasatinib-quercetin (D+Q) combination, ABT-737, and navitoclax, for one month at a two-week interval ... The researchers examined the associations of transcriptomic changes between COVID-19 patients and SARS-CoV-2-infected BOs ... Conclusions
Taken together, the study demonstrated that senescent cells accumulate in physiologically aged human BOs, with long-term senolytic intervention(s) substantially reducing cellular senescence and inflammation. Further, D+Q treatment uniquely induced anti-aging and pro-longevity gene expression changes in BOs."
Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data
"The four compounds, and in particular the top-runner piperlongumine, may be combined with quercetin to obtain natural formulas emulating the dasatinib + quercetin formula."
Senolytics show promise in combating brain aging and COVID-19 neuropathology
" ... human brain organoids (BOs) ... were treated with two doses of senolytics, such as the dasatinib-quercetin (D+Q) combination, ABT-737, and navitoclax, for one month at a two-week interval ... The researchers examined the associations of transcriptomic changes between COVID-19 patients and SARS-CoV-2-infected BOs ... Conclusions
Taken together, the study demonstrated that senescent cells accumulate in physiologically aged human BOs, with long-term senolytic intervention(s) substantially reducing cellular senescence and inflammation. Further, D+Q treatment uniquely induced anti-aging and pro-longevity gene expression changes in BOs."
https://www.news-medical.net/news/20231115/Senolytics-show-promise-in-combating-brain-aging-and-COVID-19-neuropathology.aspx
Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data
"The four compounds, and in particular the top-runner piperlongumine, may be combined with quercetin to obtain natural formulas emulating the dasatinib + quercetin formula."
https://www.nature.com/articles/s41598-024-55870-4