Did recent Buhre et al. FRONTIERS publication add to Irrgang et al. Science Immunology finding of potential immune tolerance (IgG4 class switch) among anti-S vaccinal Ab responses with repeat doses?
Did recent Buhre et al. FRONTIERS publication add to Irrgang et al. Science Immunology finding of potential immune tolerance (IgG4 class switch) among anti-S vaccinal Ab responses with repeat doses?
It appears that the IgG4 class switch & tolerance is due to the mRNA platform & with repeated doses & principally more so via Moderna shots that generate detectable long-term IgG4 responses
Dr. Alexander..  may I suggest that you have a scientific sub stack for those interested in the complexity of the immune system and its intricacies that  are beyond the comprehension of your non-medical reader. 
I would ask that you Not sequester your audience, Dr Alexander.
1) many readers already subscribe to multiple 'stacks. You run the risk of losing the eyes of those with limited time. This is the minor consideration...
2) you stratify your audience unnecessarily. I don't have philanges enough to count the number of "laymen" who've thanked their authors for laying out information that they needed to aquire new insights to comprehend. That they've understood a subject that was heretofore, "beyond them".
Don't hinder growth by segregation-enable the passion to learn.
Dr. Alexander..  may I suggest that you have a scientific sub stack for those interested in the complexity of the immune system and its intricacies that  are beyond the comprehension of your non-medical reader. 
Have you seen evidence that IgE goes up with IgG4 in MultiVaxers? FLCs?
I would ask that you Not sequester your audience, Dr Alexander.
1) many readers already subscribe to multiple 'stacks. You run the risk of losing the eyes of those with limited time. This is the minor consideration...
2) you stratify your audience unnecessarily. I don't have philanges enough to count the number of "laymen" who've thanked their authors for laying out information that they needed to aquire new insights to comprehend. That they've understood a subject that was heretofore, "beyond them".
Don't hinder growth by segregation-enable the passion to learn.