OAS, with Dengue BTW, you (can) get DHF when you, automata like, follow a particular sequence of serotypes during infections; there are four dengue serotypes, two transitions among the permutations of combinations are particularly nasty, say 4 to 2, and 2 to 3, I don't recall I read it in a scientific paper. In principle, = my inference,…
OAS, with Dengue BTW, you (can) get DHF when you, automata like, follow a particular sequence of serotypes during infections; there are four dengue serotypes, two transitions among the permutations of combinations are particularly nasty, say 4 to 2, and 2 to 3, I don't recall I read it in a scientific paper. In principle, = my inference, with some luck, you can be naturally immunized against dengue without having to go through DHF, e.g., myself. Dengue also is some kind of portmanteau, *dandified gait*, for how you walk (when you don't have the hemorrhagic form!, I have seen a few DHFs), i.e., like a dandy because of the pain in the joints... I know what I'm talking about.
I have lived 25 years in Padang, Sumatra, and now two in Yogya, Java. In Padang I saw several cases of dengue, several of HDF, in the different age groups, among children and adults. I never saw my wife, a Minangkabau, suffer from it because she was probably already immune; my youngest daughter had sub-HDF, atypical, with no visible bleeding, but a leakage was measurable, when she was 10 or 12 years old, in fact for a week we had hospital laboratory blood checkups until the values had returned to normal, I had preferred not to hospitalize her. For a woman in her twenties who was an acquaintance of my wife, I had donated blood for transfusion being of the same group and rhesus because she suffered from DHF just when she was about to give birth with the doctors not wanting to intervene with medical therapies preferring transfusion; a few days the woman gave birth to a baby girl in good condition.
I didn't answer your question, "You raised a key issue for that vaccine was stopped, no? I think plasma leakage syndrome??" I am not a doctor, I can't. I imagine, a vaccine should act on the four serotypes in sync, is it feasible? Another possibility, I am guessing as a layman, would be to immunize according to a line of favorable serotypes, number m, n, o, p, one separated from the other at intervals of months, feasible for those who have never been exposed to the virus and go on vacation to certain risk regions. Typically, the situations are always much more complicated than imagined. Another case infinitely and devilishly more complex than one thinks is the one with the malaria plasmodium.
OAS, with Dengue BTW, you (can) get DHF when you, automata like, follow a particular sequence of serotypes during infections; there are four dengue serotypes, two transitions among the permutations of combinations are particularly nasty, say 4 to 2, and 2 to 3, I don't recall I read it in a scientific paper. In principle, = my inference, with some luck, you can be naturally immunized against dengue without having to go through DHF, e.g., myself. Dengue also is some kind of portmanteau, *dandified gait*, for how you walk (when you don't have the hemorrhagic form!, I have seen a few DHFs), i.e., like a dandy because of the pain in the joints... I know what I'm talking about.
very very interesting. You raised a key issue for that vaccine was stopped, no? I think plasma leakage syndrome??
I have lived 25 years in Padang, Sumatra, and now two in Yogya, Java. In Padang I saw several cases of dengue, several of HDF, in the different age groups, among children and adults. I never saw my wife, a Minangkabau, suffer from it because she was probably already immune; my youngest daughter had sub-HDF, atypical, with no visible bleeding, but a leakage was measurable, when she was 10 or 12 years old, in fact for a week we had hospital laboratory blood checkups until the values had returned to normal, I had preferred not to hospitalize her. For a woman in her twenties who was an acquaintance of my wife, I had donated blood for transfusion being of the same group and rhesus because she suffered from DHF just when she was about to give birth with the doctors not wanting to intervene with medical therapies preferring transfusion; a few days the woman gave birth to a baby girl in good condition.
I didn't answer your question, "You raised a key issue for that vaccine was stopped, no? I think plasma leakage syndrome??" I am not a doctor, I can't. I imagine, a vaccine should act on the four serotypes in sync, is it feasible? Another possibility, I am guessing as a layman, would be to immunize according to a line of favorable serotypes, number m, n, o, p, one separated from the other at intervals of months, feasible for those who have never been exposed to the virus and go on vacation to certain risk regions. Typically, the situations are always much more complicated than imagined. Another case infinitely and devilishly more complex than one thinks is the one with the malaria plasmodium.
*a few days later, the woman...