Did Avolio et al. show microvascular disease following COVID infection/disease? Yes! Spike protein disrupts human cardiac pericytes function (& we can positively extrapolate findings to mRNA vaccine)
through CD147 receptor-mediated signalling; potential non-infective mechanism of mRNA vaccine related disease! Heart pericytes take up LNPs, mRNA & expresses spike on its surface; then attacked!
https://pubmed.ncbi.nlm.nih.gov/34807265/
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a broad range of clinical responses including prominent microvascular damage. The capacity of SARS-CoV-2 to infect vascular cells is still debated. Additionally, the SARS-CoV-2 Spike (S) protein may act as a ligand to induce non-infective cellular stress. We tested this hypothesis in pericytes (PCs), which are reportedly reduced in the heart of patients with severe coronavirus disease-2019 (COVID-19). Here we newly show that the in vitro exposure of primary human cardiac PCs to the SARS-CoV-2 wildtype strain or the α and δ variants caused rare infection events.
Exposure to the recombinant S protein alone elicited signalling and functional alterations, including: (1) increased migration, (2) reduced ability to support endothelial cell (EC) network formation on Matrigel, (3) secretion of pro-inflammatory molecules typically involved in the cytokine storm, and (4) production of pro-apoptotic factors causing EC death. Next, adopting a blocking strategy against the S protein receptors angiotensin-converting enzyme 2 (ACE2) and CD147, we discovered that the S protein stimulates the phosphorylation/activation of the extracellular signal-regulated kinase 1/2 (ERK1/2) through the CD147 receptor, but not ACE2, in PCs.
The neutralisation of CD147, either using a blocking antibody or mRNA silencing, reduced ERK1/2 activation, and rescued PC function in the presence of the S protein. Immunoreactive S protein was detected in the peripheral blood of infected patients. In conclusion, our findings suggest that the S protein may prompt PC dysfunction, potentially contributing to microvascular injury.’
Note: pericytes wrap around the endothelial (potentially glycocalyx) layer that lines the capillaries of the vasculature.
Microvasculature disease leads to impaired kidney, lung, liver function and thus impaired filtration of toxins. The skin is a large organ in itself, and has many function related to immunity, including protection of the body from the outside in, and inside out. When filtration fails to remove toxins, they continue to circulate and end up in the lymphatic system and capillaries. Any foreign matter, any toxins that lymphocytes cannot destroy, are encapsulated for later processing, and/or ejected through the skin. If not encapsulated and neutralized, the particles cause irritation, inflammation, damage on the way out, causing a rash. Bacterial blooms occur as bacteria feed on dead and damaged, erupted & inflamed skin. Sores develop. Monkeypox.
mRNA haccines make your cells produce that lethal spike protein until they die!!! or even more, since it was found they had double-stranded DNA to make sure that the replacing cell would produce that poison forever.
The REAL COVID timeline:
It’s a Bio-BOMB, yet less lethal than like the vx ... not what you were drilled
https://scientificprogress.substack.com/p/the-real-covid-timeline
Bio-BOMB, not “vaccine”, not “gene-therapy”
This 5th gen war, includes a war on semantics.
https://scientificprogress.substack.com/p/not-vaccine-not-gene-therapy-just
What do bioweapons have to do with the Department of Energy?
Anybody answering these questions PLEASE ? !!!
https://scientificprogress.substack.com/p/what-do-bioweapons-have-to-do-with