Does the vaccine-induced spike protein from COVID mRNA technology gene based vaccination subvert critical tumor suppressor proteins e.g. p53 and BRCA-1/2 proteins; p53 and BRCA are the well-known

tumor suppressor proteins, that regulate downstream genes in response to numerous cellular stress and are frequently mutated in human cancer (Singh et al.) Translational Oncology Volume 13, Issue 10

https://www.sciencedirect.com/science/article/pii/S1936523320303065?via%3Dihub

‘S2 subunit of SARS-nCov-2 strongly interacts with p53 and BRCA-1/2 proteins (Figure 1). p53 and BRCA are the well-known tumor suppressor proteins, that regulate downstream genes in response to numerous cellular stress and are frequently mutated in human cancer [5,6]. Interestingly we found p53, BRCA-1 and BRCA-2 interact with heptic repeat-2 region of S2 subunit through C- terminal domain. PDB ID of these proteins was extracted from RCSB Protein Data Base (PDB) and details of crystal structure IDs and interacted amino acid residues are mentioned in the figure legend. This short bioinformatic analysis is a first time report and significant since COVID-19 is more fatal in people with underlying conditions specially lung diseases, diabetes and cancer.’

Figure 1. Analysis of S2 subunit of SARS-nCoV-2 interaction with tumor suppressor proteins. (A) Interaction between S2 Subunit of nCoV (Green color PDB ID: 6LXT [4] asp 1165, leu 1166, asn 1173) with p53 protein (Cyan color PDB ID: 3EXJ [7] thr 281, arg 270, arg 277, his 175) (B) Interaction between S2 Subunit of nCoV (Green color PDB ID: 6LXT [4] asp 1165, gly 1171, asn 1173) with BRCA-1 protein (Cyan color PDB ID: 4Y18 [8] lys 1648, arg 1649, his 1672) (C) Interaction between S2 Subunit of nCoV (Green color PDB ID: 6LXT [4] asp 1165, leu 1166, ser 1175) with BRCA-2 protein (Cyan color PDB ID: 3EU7 [9] glu 916, leu 938, arg 1117). HR: hepted repeat.