IgG4 antibody 'class switch' (Immune 'Tolerance') shown by Valk et al. adds to growing body of evidence; are the mRNA technology gene based vaccines (Weissman, Kariko, Malone, Bourla, Bancel, Sahin)..
subverting the immune system, ransacking it, rewiring it with potentially harmful deadly effects? Results imply (via 3rd shot) a major role for both IL-4/IL-13 as well as TNF in IgG4 class switching.
https://www.medrxiv.org/content/10.1101/2023.09.29.23296354v1
‘Results We observed a substantial increase in the proportion of RBD-specific IgG4 antibodies (median 21%) in healthy/untreated controls after a third mRNA vaccination. This IgG4 skewing was absent when primary vaccination was adenoviral vector-based and was profoundly reduced in both dupilumab- and TNFi-treated patients (<1%), but only moderately in patients treated with MTX (7%).’
Point is when vaccinees get the third vaccine it appears (mRNA Pfizer, Moderna etc.) that there is this IgG4 class swith to antibodies (immune to the antigen, in this case the spike antigen) that play a major role in immune tolerance. Remember, the IgG4 immune tolerance antibodies comprise a very small fraction of the IgG antibodies e.g. 1-2% roughly. The implications can be horrendous meaning with boosters, you get more accustomed to the vaccine, the induced antibodies will have no impact on the target antigen (spike protein) and you could actually be very very vulnerable to infection and if pathological, severe illness.
What is the long-term impact of the mRNA vaccine on the immune system, long-term? Are there poison pills? Is our military and police at serious risk? Our first responders? Normally healthy people who were duped into taking the shots and boosters? Does this class-swith link to autoreactivity? Autoimmunity?
This was never needed, this COVID vaccine, and all those linked to the mRNA vaccine must be investigated and jailed if shown they knew and still consipred to harm people.
Remember this paper by Irrgang et al. I had written about in a prior substack on IgG4 class-switch:
IgG4 'class switch' (Irrgang et al.) toward noninflammatory, spike-specific IgG4 antibodies after repeated COVID mRNA vaccination; a problem for mRNA technology based gene injected vaccinees? YES!
https://pubmed.ncbi.nlm.nih.gov/36548397/ ‘High levels of neutralizing SARS-CoV-2 antibodies are an important component of vaccine-induced immunity. Shortly after the initial two mRNA vaccine doses, the immunoglobulin G (IgG) response mainly consists of the proinflammatory subclasses IgG1 and IgG3. Here, we report that several months after the second vac…
As we gain more & more understanding of the actual mechanisms by which the multidimensional harms to immune function have been achieved, the one thing we pretty much knew (or at the very least strongly suspected) from the outset only becomes more evident and undeniable: none of it was accidental or the result of error
I remain 100% convinced this was known at the time by the "pushers".
I was always very curious as to why Boris Johnston and others in the UK got frankly "frantic" over the need for all to have the so called booster jab and Johnston in particular started talking about mandating the jab to face the issue. Never happened but as I say the pressure at the time to have such was huge (A pressure I wholly ignored)
I reckon we still only know a fraction of what has gone on in the name of "health" but it's clearly and deliberately got nothing to do with health. Quite the opposite I suspect.