Is COVID sub-variant BA.2.86 & driven largely by natural selection pressure & due to a leaky 'imperfect' sub-optimal non-sterilizing, non-neutralizing mRNA vaccine more deadly than prior variants? Is

this FEAR porn? Driving fear! We have no evidence that BA.2.86 is more deadly, no data & yes, it is more infectious and fusogenic, yet we must keep in mind that Fauci, Francis Collins, Baric, Daszak,

Menachery et al. brought a pathogen in the first place, something, something that was released at some point, with seemingly many ‘poison pills’ and maybe based on work in multiple labs e.g. Chapel Hill, Wuhan, Ukraine, PHAC Canada etc….something that caused serious enough respiratory symptoms in high-risk vulnerable elderly. Let us not fool ourselves.

Poison pills.

These evil people did bad, they brought something that IMO was always circulating and they used the PCR ‘process’ to detect something they knew was always circulating.

Something that Menachery et al. said in their report that they had just basically created A MONSTER INFECTIOUS VIRUS. We are here because of the work, deadly work of Menachery et al. IMO.

See Menachery et al.

‘Using the SARS-CoV reverse genetics system², we generated and characterized a chimeric virus expressing the spike of bat coronavirus SHC014 in a mouse-adapted SARS-CoV backbone. The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently use multiple orthologs of the SARS receptor human angiotensin converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV. Additionally, in vivo experiments demonstrate replication of the chimeric virus in mouse lung with notable pathogenesis. Evaluation of available SARS-based immune-therapeutic and prophylactic modalities revealed poor efficacy; both monoclonal antibody and vaccine approaches failed to neutralize and protect from infection with CoVs using the novel spike protein. On the basis of these findings, we synthetically re-derived an infectious full-length SHC014 recombinant virus and demonstrate robust viral replication both in vitro and in vivo. Our work suggests a potential risk of SARS-CoV re-emergence from viruses currently circulating in bat populations.’

The COVID pandemic we know was a fake fraud, 100%, it was never a pandemic and that is not the issue of this substack. I am focusing on the fact that something was circulating that killed some elderly and high-risk early on (maybe was circluating for years at a benign low level) with medical conditions yet acknowledging that the vast majority died due to denied treatments (only use of COVID beds), the collaterol damage of lockdowns, the vaccine itself, and mostly, from the medical management e.g. isolation, sedation (propofol, midazolam, lorazepam, morphine etc.), DNR orders, denial of antibiotics for likely bacterial pneumonia, dehydration, malnourichment of the elderly, Remdesivir (kidney and liver toxic), and then being placed on the ventilator blowing holes in the lungs and ventilator associated pneumonia.

So is this fear porn by seriously dark, malevolent, evil motherfuck*rs again to drive you to lock down, wear the ineffective toxic surgical and cloth masks again, and drive you to take your 8th booster with a booster that has failed and is non-sterilizing, drives original antigenic sin, antibiody-dependent enhancement of infection, and viral immune escape (mismatch between vaccine spike and circulating dominant virus spike protein), as well as immune tolerance (IgG 4 class-switch)? Is it? I think so. I see no indications thus far that this is more lethal and pathological. Yet we do due diligence by keeping an eye on this sub-variant. More infectious does not mean more lethal yet if this variant threatens the lower lung cells, this may pose a problem to at risk people. It is very likley that natural immunity (not vaccinal immunity) will provide the protection needed. Immune evasion, infectivity, and fusogenicity does not MEAN lethality yet it is recognized that any virus e.g. common colds, flu even, will pose an immune challenge to elderly, high-risk persons. We always strongly protect the high-risk VULNERABLE first. Protect them taking sensible reasonable precautions.

The Daily Mail said that the new fast spreading BA.2.86 may be more deadly than earlier versions. Yet this is the type of irresponsible reporting by Dail Mail and we ask, can you point us to any data to show that it is more deadly, as of the writing of this substack? Being more infectious is not concerning if not more lethal. Again, we focus on protecting the vulnerable who succumb to even common colds.

Yet we keep an eye on this. I am not sold on this reporting by Daily Mail. Yet the fact that ‘BA.2.86 can infect human cells that line the lower lung and can enter cell membranes more efficiently’ is something we pay attention to across time.

Point is dark malevolent people did something wrong with pathogen and we are here because of that.

https://www.sciencedirect.com/science/article/pii/S0092867423014009#sec3

Researchers ‘characterized BA.2.86 and XBB-derived variant FLip by investigating their neutralization alongside D614G, BA.1, BA.2, BA.4/5, XBB.1.5, and EG.5.1 by sera from 3-dose-vaccinated and bivalent-vaccinated healthcare workers, XBB.1.5-wave-infected first responders, and monoclonal antibody (mAb) S309.

…assessed the biology of the variant spikes by measuring viral infectivity and membrane fusogenicity.

…BA.2.86 is less immune evasive compared to FLip and other XBB variants, consistent with antigenic distances.

…Importantly, distinct from XBB variants, mAb S309 was unable to neutralize BA.2.86, likely due to a D339H mutation based on modeling.

…BA.2.86 had relatively high fusogenicity and infectivity in CaLu-3 cells but low fusion and infectivity in 293T-ACE2 cells compared to some XBB variants, suggesting a potentially different conformational stability of BA.2.86 spike.’