Mishra et al.'s study "SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia"; simply, microRNAs (miRNAs) inhibited molecules that activated IFN-alpha/beta
Seneff: implies that vaccinated individuals will have a reduced IFN-alpha/beta response and poorer immune clearance para; reduced symptoms in the vaccinated are likely because of this reduced pathway
‘Spike transfected cells release a significant amount of exosomes loaded with microRNAs such as miR-148a and miR-590. microRNAs gets internalized by human microglia and suppress target gene expression of USP33 (Ubiquitin Specific peptidase 33) and downstream IRF9 levels. Cellular levels of USP33 regulate the turnover time of IRF9 via deubiquitylation. Our results also demonstrate that absorption of modified exosomes effectively regulate the major pro-inflammatory gene expression profile of TNFα, NF-κB and IFN-β. These results uncover a bystander pathway of SARS-CoV-2 mediated CNS damage through hyperactivation of human microglia.’
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