7 studies that help explain why the vaccinated are getting more infected; IMO, natural immunity is not breached; the non-neutralizing Abs bind to the virus spike, & enhances infectiousness of virus

there is binding but non-neutralizing antibodies don't sterilize the virus & does not eliminate it; non-neutralizing Abs enhance or facilitate infection in host cells; ADE, original antigenic sin, OAS

Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination?

Yahi et al.: so it is the binding to the virus by non-neutralizing Abs that do not eliminate the virus but increases infectiousness…it enhances the infection capability and explains why the vaccinated are getting infected; the non-neutralizing Abs bind to the virus in the upper respiratory tract and drive infection yet binds to the lower respiratory tract and prevents severe disease (transfection from infected to non-infected cells). This study shows original antigenic sin and ADE and as Vanden Bossche asserts, there is subversion of the natural innate and natural acquired-adaptive immune response.

“our data suggest that the balance between neutralizing and facilitating antibodies in vaccinated individuals is in favor of neutralization for the original Wuhan/D614G strain. However, in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity. Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors).”

The 7 key studies are:

1)Van Egeren et al.: “Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein”

2)Yahi et al.: Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination?

3)An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies

4)Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies

5)Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia

6)The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages

7)The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic